U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Npc2e Niemann-Pick type C-2e [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326136, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Npc2eprovided by FlyBase
    Official Full Name
    Niemann-Pick type C-2eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051410
    Locus tag
    Dmel_CG31410
    See related
    AllianceGenome:FB:FBgn0051410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31410; CG3928; Dmel\CG31410; npc2e
    Summary
    Enables several functions, including lipopolysaccharide binding activity; lipoteichoic acid binding activity; and peptidoglycan binding activity. Involved in positive regulation of defense response to bacterium. Located in extracellular space. Is expressed in embryonic/larval midgut. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Npc2e in Genome Data Viewer
    Location:
    85F8-85F8; 3-49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10053332..10054348)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5879054..5880070)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitochondrial transcription factor B2 Neighboring gene uncharacterized protein Neighboring gene ohgata Neighboring gene antisense RNA:CR44192 Neighboring gene fancl Neighboring gene Niemann-Pick type C-2d Neighboring gene antisense RNA:CR45205 Neighboring gene Niemann-Pick type C-2c

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Drosophila DHR96 nuclear receptor binds cholesterol and regulates cholesterol homeostasis. Horner MA, et al. Genes Dev, 2009 Dec 1. PMID 19952106, Free PMC Article
    2. Drosophila melanogaster NPC2 proteins bind bacterial cell wall components and may function in immune signal pathways. Shi XZ, et al. Insect Biochem Mol Biol, 2012 Aug. PMID 22580186, Free PMC Article
    3. Drosophila Niemann-Pick type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease. Huang X, et al. Development, 2007 Oct. PMID 17804599
    4. Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease. Garrido-Maraver J, et al. Biol Open, 2020 Jan 14. PMID 31822473, Free PMC Article
    5. The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila. Sieber MH, et al. Cell Metab, 2009 Dec. PMID 19945405, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipid antigen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipoteichoic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sterol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of defense response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sterol transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Niemann-Pick type C-2e
    Names
    CG31410-PB
    Npc2e-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10053332..10054348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169323.3 → NP_731439.2  Niemann-Pick type C-2e [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731439.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9PTV0, Q9VH33
      Conserved Domains (1) summary
      cl00274
      Location:20 → 144
      ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VH33 Q9VH33

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools