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    Loxl1 Lysyl oxidase-like 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43712, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Loxl1provided by FlyBase
    Official Full Name
    Lysyl oxidase-like 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0039848
    Locus tag
    Dmel_CG11335
    See related
    AllianceGenome:FB:FBgn0039848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11335; Dmel\CG11335; dmlox-1; Dmloxl-1; DmLOXL-1; DmLOXL1; lox; Lox; LOX
    Summary
    Enables copper ion binding activity and protein-lysine 6-oxidase activity. Predicted to be involved in protein modification process. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in organism. Human ortholog(s) of this gene implicated in myopia. Orthologous to human LOXL2 (lysyl oxidase like 2) and LOXL3 (lysyl oxidase like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Loxl1 in Genome Data Viewer
    Location:
    100C4-100C4; 3-102 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31458380..31459869, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27284102..27285591, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Gcn2 Neighboring gene Polynucleotide phosphorylase Neighboring gene G protein-coupled receptor kinase 2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45554 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Formation of lysine tyrosylquinone (LTQ) is a self-processing reaction. Expression and characterization of a Drosophila lysyl oxidase. Bollinger JA, et al. Biochemistry, 2005 Sep 6. PMID 16128571
    2. Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase. Rao G, et al. Biochemistry, 2017 Jul 25. PMID 28660757
    3. Drosophila lysyl oxidases Dmloxl-1 and Dmloxl-2 are differentially expressed and the active DmLOXL-1 influences gene expression and development. Molnar J, et al. J Biol Chem, 2005 Jun 17. PMID 15811848
    4. Regulation of the collagen IV network by the basement membrane protein perlecan is crucial for squamous epithelial cell morphogenesis and organ architecture. Bonche R, et al. Matrix Biol, 2022 Dec. PMID 36343860
    5. Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos. Stramer B, et al. EMBO Rep, 2008 May. PMID 18344972, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. possible interactions between the LOX inhibitor BAPN (beta-aminopropionitrile; 1-[(13)C(15)N]cyano-2-aminoethane) and the copper center-finding none.
      Title: Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase.
    2. Dmloxl-1 and Dmloxl-2 are differentially expressed; active DmLOXL-1 influences gene expression and development
      Title: Drosophila lysyl oxidases Dmloxl-1 and Dmloxl-2 are differentially expressed and the active DmLOXL-1 influences gene expression and development.
    3. cofactor in the active, copper-containing enzyme is lysine tyrosylquinone (LTQ); LTQ biogenesis most likely occurs by self-processing chemistry, requiring only the precursor protein, copper, and oxygen
      Title: The Formation of lysine tyrosylquinone (LTQ) is a self-processing reaction. Expression and characterization of a Drosophila lysyl oxidase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-lysine 6-oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-lysine 6-oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-lysine 6-oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein modification process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysyl oxidase-like 1
    Names
    CG11335-PA
    Loxl1-PA
    lysyl oxidase
    lysyl oxidase-like
    lysyl oxidase-like protein L1
    NP_524607.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31458380..31459869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079868.3 → NP_524607.1  lysyl oxidase-like 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PV29, Q9V9X5
      Related
      FBpp0085171
      Conserved Domains (3) summary
      smart00202
      Location:50 → 136
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:50 → 137
      SRCR; Scavenger receptor cysteine-rich domain
      pfam01186
      Location:149 → 343
      Lysyl_oxidase; Lysyl oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V9X5 Q9V9X5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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