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    CG12320 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42189, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12320provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038590
    Locus tag
    Dmel_CG12320
    See related
    AllianceGenome:FB:FBgn0038590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aar2; Dmel\CG12320
    Summary
    Predicted to be involved in spliceosomal tri-snRNP complex assembly. Located in cytoplasm. Part of small nuclear ribonucleoprotein complex. Orthologous to human AAR2 (AAR2 splicing factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12320 in Genome Data Viewer
    Location:
    90F10-90F10; 3-62 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18251069..18252734, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14077220..14078456, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene reversed polarity Neighboring gene uncharacterized protein Neighboring gene 14-3-3epsilon Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II subunit D Neighboring gene transcriptional Adaptor 2a Neighboring gene Trimethylguanosine synthase 1 Neighboring gene modigliani

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The homologous Drosophila transcriptional adaptors ADA2a and ADA2b are both required for normal development but have different functions. Pankotai T, et al. Mol Cell Biol, 2005 Sep. PMID 16135810, Free PMC Article
    2. Unexpected role of the steroid-deficiency protein ecdysoneless in pre-mRNA splicing. Claudius AK, et al. PLoS Genet, 2014 Apr. PMID 24722212, Free PMC Article
    3. Striking circadian neuron diversity and cycling of Drosophila alternative splicing. Wang Q, et al. Elife, 2018 Jun 4. PMID 29863472, Free PMC Article
    4. Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet. Çiçek IÖ, et al. Genetics, 2016 Mar. PMID 26801178, Free PMC Article
    5. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in spliceosomal tri-snRNP complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of U5 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of small nuclear ribonucleoprotein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12320-PA
    CG12320-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18251069..18252734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316550.1 → NP_001303479.1  uncharacterized protein Dmel_CG12320, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P44, Q9VEA6
      Conserved Domains (3) summary
      cd13777
      Location:23 → 152
      Aar2_N; N-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor
      cd13778
      Location:211 → 359
      Aar2_C; C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor
      pfam05282
      Location:21 → 360
      AAR2; AAR2 protein

    2. NM_142442.2 → NP_650699.1  uncharacterized protein Dmel_CG12320, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650699.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P44, Q9VEA6
      Related
      FBpp0083025
      Conserved Domains (3) summary
      cd13777
      Location:23 → 152
      Aar2_N; N-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor
      cd13778
      Location:211 → 359
      Aar2_C; C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor
      pfam05282
      Location:21 → 360
      AAR2; AAR2 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86P44 Q86P44
    Q9VEA6 Q9VEA6

    Gene LinkOut

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