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    l(3)neo38 lethal (3) neo38 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41423, updated on 27-Dec-2024

    Summary

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    Official Symbol
    l(3)neo38provided by FlyBase
    Official Full Name
    lethal (3) neo38provided by FlyBase
    Primary source
    FLYBASE:FBgn0265276
    Locus tag
    Dmel_CG6930
    See related
    AllianceGenome:FB:FBgn0265276
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe2F4; anon2F4; BcDNA:SD16005; CG14725; CG31364; CG6930; Dmel\CG6930; l(3)NEO38; L(3)neo38
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in brain development and neuromuscular junction development. Located in heterochromatin. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; head epidermis primordium; sensory nervous system primordium; and ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(3)neo38 in Genome Data Viewer
    Location:
    86E18-86E18; 3-51 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11765038..11779128, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7590760..7604850, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Lk6 kinase Neighboring gene long non-coding RNA:CR45595 Neighboring gene pruning defect 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lineage-Resolved Enhancer and Promoter Usage during a Time Course of Embryogenesis. Reddington JP, et al. Dev Cell, 2020 Dec 7. PMID 33171098
    2. Identification of genomic enhancers through spatial integration of single-cell transcriptomics and epigenomics. Bravo González-Blas C, et al. Mol Syst Biol, 2020 May. PMID 32431014, Free PMC Article
    3. Genome-wide analysis of promoter architecture in Drosophila melanogaster. Hoskins RA, et al. Genome Res, 2011 Feb. PMID 21177961, Free PMC Article
    4. NuRD-independent Mi-2 activity represses ectopic gene expression during neuronal maturation. Aughey GN, et al. EMBO Rep, 2023 Apr 5. PMID 36722816, Free PMC Article
    5. The GAGA factor regulatory network: Identification of GAGA factor associated proteins. Lomaev D, et al. PLoS One, 2017. PMID 28296955, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lethal (3) neo38
    Names
    CG6930-PA
    CG6930-PB
    CG6930-PC
    CG6930-PD
    CG6930-PF
    CG6930-PG
    CG6930-PI
    CG6930-PJ
    CG6930-PK
    CG6930-PL
    anon-fast-evolving-2F4
    l(3)neo38-PA
    l(3)neo38-PB
    l(3)neo38-PC
    l(3)neo38-PD
    l(3)neo38-PF
    l(3)neo38-PG
    l(3)neo38-PI
    l(3)neo38-PJ
    l(3)neo38-PK
    l(3)neo38-PL

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11765038..11779128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043243.3 → NP_001036708.1  lethal (3) neo38, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036708.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSP5
      Conserved Domains (2) summary
      COG5048
      Location:341 → 409
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001260134.2 → NP_001247063.1  lethal (3) neo38, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247063.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6S1
      Conserved Domains (3) summary
      sd00017
      Location:246 → 266
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:258 → 283
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:219 → 304
      zf-C2H2_8; C2H2-type zinc ribbon

    3. NM_001260131.2 → NP_001247060.1  lethal (3) neo38, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6S1
      Conserved Domains (3) summary
      sd00017
      Location:246 → 266
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:258 → 283
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:219 → 304
      zf-C2H2_8; C2H2-type zinc ribbon

    4. NM_001260136.2 → NP_001247065.1  lethal (3) neo38, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247065.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0R905
      Conserved Domains (2) summary
      COG5048
      Location:328 → 396
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:320 → 340
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001260133.2 → NP_001247062.1  lethal (3) neo38, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247062.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6F4
      Conserved Domains (2) summary
      COG5048
      Location:267 → 335
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001043244.3 → NP_001036709.1  lethal (3) neo38, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036709.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSP5
      Conserved Domains (2) summary
      COG5048
      Location:341 → 409
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001275556.2 → NP_001262485.1  lethal (3) neo38, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262485.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGA3
      Conserved Domains (3) summary
      sd00017
      Location:333 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:345 → 370
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:306 → 391
      zf-C2H2_8; C2H2-type zinc ribbon

    8. NM_001260135.1 → NP_001247064.1  lethal (3) neo38, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247064.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSP5
      Conserved Domains (2) summary
      COG5048
      Location:341 → 409
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_001260130.1 → NP_001247059.1  lethal (3) neo38, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247059.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6F4
      Conserved Domains (2) summary
      COG5048
      Location:267 → 335
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. NM_141856.3 → NP_650113.1  lethal (3) neo38, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650113.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZN9, Q9VGI3
      Related
      FBpp0082007
      Conserved Domains (3) summary
      sd00017
      Location:266 → 286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:278 → 303
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:239 → 324
      zf-C2H2_8; C2H2-type zinc ribbon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6F4 A0A0B4K6F4
    A0A0B4K6S1 A0A0B4K6S1
    A0A0B4KGA3 A0A0B4KGA3
    E0R905 E0R905
    Q7KSP5 Q7KSP5
    Q8MRX4 Q8MRX4
    Q8SZN9 Q8SZN9

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