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    PIG-H Phosphatidylinositol glycan anchor biosynthesis class H [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40944, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIG-Hprovided by FlyBase
    Official Full Name
    Phosphatidylinositol glycan anchor biosynthesis class Hprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037535
    Locus tag
    Dmel_CG14463
    See related
    AllianceGenome:FB:FBgn0037535
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14463; Dmel\CG14463; PIGH
    Summary
    Predicted to be involved in GPI anchor biosynthetic process. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Orthologous to human PIGH (phosphatidylinositol glycan anchor biosynthesis class H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PIG-H in Genome Data Viewer
    Location:
    84E8-84E8; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7999832..8001064)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3825554..3826786)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46143 Neighboring gene long non-coding RNA:CR46142 Neighboring gene kinetochore Mis12-Ndc80 network component 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
    2. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
    3. A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. Pletcher RC, et al. G3 (Bethesda), 2019 Jul 9. PMID 31036678, Free PMC Article
    4. Comprehensive Identification and Alternative Splicing of Microexons in Drosophila. Pang TL, et al. Front Genet, 2021. PMID 33859668, Free PMC Article
    5. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol glycan anchor biosynthesis class H
    Names
    CG14463-PA
    CG14463-PB
    PIG-H-PA
    PIG-H-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7999832..8001064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275429.1 → NP_001262358.1  phosphatidylinositol glycan anchor biosynthesis class H, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262358.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHX6
      Conserved Domains (1) summary
      pfam10181
      Location:121 → 178
      PIG-H; GPI-GlcNAc transferase complex, PIG-H component

    2. NM_141498.3 → NP_649755.1  phosphatidylinositol glycan anchor biosynthesis class H, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHX6
      Related
      FBpp0081279
      Conserved Domains (1) summary
      pfam10181
      Location:121 → 178
      PIG-H; GPI-GlcNAc transferase complex, PIG-H component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHX6 Q9VHX6

    Gene LinkOut

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