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    SecCl Secretory chloride channel [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SecClprovided by FlyBase
    Official Full Name
    Secretory chloride channelprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036727
    Locus tag
    Dmel_CG7589
    See related
    AllianceGenome:FB:FBgn0036727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7589; CT23187; Dmel\CG7589; Lcch-74C; secCl
    Summary
    Enables pH-gated chloride channel activity. Involved in several processes, including glycinergic synaptic transmission; negative regulation of neuronal action potential; and transepithelial chloride transport. Predicted to be located in membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in several structures, including adult central brain; adult gut; epithelial tube; gut section; and salivary gland. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SecCl in Genome Data Viewer
    Location:
    74C3-74C3; 3-45 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17470127..17474517)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17463227..17467617)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44565 Neighboring gene QIL1 Neighboring gene Ubiquinol-cytochrome c reductase ubiquinone-binding protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila. Feingold D, et al. Sci Rep, 2019 May 16. PMID 31097722, Free PMC Article
    2. The orphan pentameric ligand-gated ion channel pHCl-2 is gated by pH and regulates fluid secretion in Drosophila Malpighian tubules. Feingold D, et al. J Exp Biol, 2016 Sep 1. PMID 27358471
    3. Evidence for a diverse Cys-loop ligand-gated ion channel superfamily in early bilateria. Dent JA. J Mol Evol, 2006 May. PMID 16586016
    4. Molecular basis for epithelial morphogenesis and ion transport in the Malpighian tubule. Jonusaite S, et al. Curr Opin Insect Sci, 2021 Oct. PMID 33581351, Free PMC Article
    5. Two cDNAs coding for histamine-gated ion channels in D. melanogaster. Gisselmann G, et al. Nat Neurosci, 2002 Jan. PMID 11753412

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycine-gated chloride ion channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables pH-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of circadian rhythm IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, glycinergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transepithelial chloride transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    secretory chloride channel
    Names
    CG7589-PA
    CG7589-PB
    SecCl-PA
    SecCl-PB
    ligand-gated chloride channel

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17470127..17474517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275057.1 → NP_001261986.1  secretory chloride channel, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261986.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V4W9, Q9VVH4
      Conserved Domains (3) summary
      TIGR00860
      Location:43 → 505
      LIC; Cation transporter family protein
      pfam02931
      Location:44 → 267
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:275 → 503
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_140727.2 → NP_648984.2  secretory chloride channel, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648984.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V4W9, Q9VVH4
      Related
      FBpp0074983
      Conserved Domains (3) summary
      TIGR00860
      Location:43 → 505
      LIC; Cation transporter family protein
      pfam02931
      Location:44 → 267
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:275 → 503
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVH4 Q9VVH4

    Gene LinkOut

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