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    cocoon cocoon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39665, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cocoonprovided by FlyBase
    Official Full Name
    cocoonprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036496
    Locus tag
    Dmel_CG7804
    See related
    AllianceGenome:FB:FBgn0036496
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg7804; CG7804; Dmel\CG7804
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of gene expression. Predicted to be located in chromatin. Predicted to be active in nucleoplasm. Is expressed in organism. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cocoon in Genome Data Viewer
    Location:
    71D2-71D2; 3-43 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15472197..15474110, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15465297..15467210, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45395 Neighboring gene long non-coding RNA:CR45394 Neighboring gene Ran-like Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapid Evolution of Gained Essential Developmental Functions of a Young Gene via Interactions with Other Essential Genes. Lee YCG, et al. Mol Biol Evol, 2019 Oct 1. PMID 31187122, Free PMC Article
    2. Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS. Estes PS, et al. Hum Mol Genet, 2011 Jun 15. PMID 21441568, Free PMC Article
    3. Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes. Diaper DC, et al. Hum Mol Genet, 2013 Apr 15. PMID 23307927, Free PMC Article
    4. On the Origin and Evolution of Drosophila New Genes during Spermatogenesis. Su Q, et al. Genes (Basel), 2021 Nov 15. PMID 34828402, Free PMC Article
    5. Rapid Changes in the Translatome during the Conversion of Growth Cones to Synaptic Terminals. Zhang KX, et al. Cell Rep, 2016 Feb 9. PMID 26832407

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cocoon
    Names
    CG7804-PA
    CG7804-PB
    cocoon-PA
    cocoon-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15472197..15474110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140507.1 → NP_648764.1  cocoon, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648764.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUN2
      Related
      FBpp0075370, FBtr0075617
      Conserved Domains (2) summary
      cd12321
      Location:108 → 184
      RRM1_TDP43; RNA recognition motif 1 in TAR DNA-binding protein 43 (TDP-43) and similar proteins
      cd12322
      Location:193 → 262
      RRM2_TDP43; RNA recognition motif 2 in TAR DNA-binding protein 43 (TDP-43) and similar proteins

    2. NM_001274945.1 → NP_001261874.1  cocoon, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261874.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUN2
      Conserved Domains (2) summary
      cd12321
      Location:108 → 184
      RRM1_TDP43; RNA recognition motif 1 in TAR DNA-binding protein 43 (TDP-43) and similar proteins
      cd12322
      Location:193 → 262
      RRM2_TDP43; RNA recognition motif 2 in TAR DNA-binding protein 43 (TDP-43) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUN2 Q9VUN2

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