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    Spt20 Spt20 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39522, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spt20provided by FlyBase
    Official Full Name
    Spt20provided by FlyBase
    Primary source
    FLYBASE:FBgn0036374
    Locus tag
    Dmel_CG17689
    See related
    AllianceGenome:FB:FBgn0036374
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17689; Dmel\CG17689; dSpt20; lincRNA.S5070
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in chromatin organization and regulation of transcription by RNA polymerase II. Located in nucleus. Part of SAGA complex. Is expressed in chordotonal neurons. Orthologous to several human genes including SUPT20H (SPT20 homolog, SAGA complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spt20 in Genome Data Viewer
    Location:
    70B3-70B4; 3-40 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13502707..13511541)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13495807..13504641)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Actin binding protein 1 Neighboring gene Tondu-domain-containing Growth Inhibitor Neighboring gene Liprin-beta Neighboring gene Vacuolar protein sorting 36 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SAGA core module is critical during Drosophila oogenesis and is broadly recruited to promoters. Soffers JHM, et al. PLoS Genet, 2021 Nov. PMID 34807910, Free PMC Article
    2. Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration. Mohan RD, et al. Genes Dev, 2014 Feb 1. PMID 24493646, Free PMC Article
    3. What do the structures of GCN5-containing complexes teach us about their function? Helmlinger D, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Feb. PMID 32739556
    4. Function and regulation of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) deubiquitinase module. Cornelio-Parra DV, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Feb. PMID 32911111
    5. The gang of four gene regulates growth and patterning of the developing Drosophila eye. Beam CK, et al. Fly (Austin), 2010 Apr-Jun. PMID 20473027, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SAGA-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Spt20
    Names
    CG17689-PA
    CG17689-PC
    CG17689-PD
    Spt20-PA
    Spt20-PC
    Spt20-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13502707..13511541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140402.5 → NP_648659.2  Spt20, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648659.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U0Z4, Q9VU86
      Conserved Domains (1) summary
      pfam12090
      Location:429 → 559
      Spt20; Spt20 family

    2. NM_001038916.3 → NP_001034005.2  Spt20, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034005.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDX8
      Conserved Domains (1) summary
      pfam12090
      Location:429 → 559
      Spt20; Spt20 family

    3. NM_001300133.1 → NP_001287062.1  Spt20, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287062.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U0Z4, Q9VU86
      Conserved Domains (1) summary
      pfam12090
      Location:429 → 559
      Spt20; Spt20 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2PDX8 Q2PDX8
    Q9VU86 Q9VU86

    Gene LinkOut

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