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    NijA Ninjurin A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39215, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NijAprovided by FlyBase
    Official Full Name
    Ninjurin Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036101
    Locus tag
    Dmel_CG6449
    See related
    AllianceGenome:FB:FBgn0036101
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6449; Dmel\CG6449; nija; nijA; ninA; NINJ-A
    Summary
    Involved in several processes, including cell adhesion; cytolysis; and negative regulation of cell adhesion. Is active in extracellular region and plasma membrane. Is expressed in larval optic neuroblast. Orthologous to human NINJ1 (ninjurin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NijA in Genome Data Viewer
    Location:
    67E7-67E7; 3-33 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10694360..10696877, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10687460..10689977, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 13 kDa B subunit Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44544

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Ninjurin A induces nonapoptotic cell death. Broderick S, et al. PLoS One, 2012. PMID 23028562, Free PMC Article
    2. NINJ1 mediates plasma membrane rupture during lytic cell death. Kayagaki N, et al. Nature, 2021 Mar. PMID 33472215
    3. Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila. Patterson RA, et al. PLoS One, 2013. PMID 23637905, Free PMC Article
    4. Rapid genomic changes in Drosophila melanogaster adapting to desiccation stress in an experimental evolution system. Kang L, et al. BMC Genomics, 2016 Mar 15. PMID 26979755, Free PMC Article
    5. HITS-CLIP reveals sex-differential RNA binding and alterative splicing regulation of SRm160 in Drosophila. Qiu C, et al. J Mol Cell Biol, 2019 Feb 1. PMID 29750417, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in programmed cell death IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tissue regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ninjurin A
    Names
    CG6449-PA
    CG6449-PB
    CG6449-PC
    CG6449-PD
    NijA-PA
    NijA-PB
    NijA-PC
    NijA-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      10694360..10696877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274758.2 → NP_001261687.1  ninjurin A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261687.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHZ8
      Conserved Domains (1) summary
      pfam04923
      Location:110 → 210
      Ninjurin; Ninjurin

    2. NM_140153.5 → NP_648410.1  ninjurin A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648410.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTB5
      Related
      FBpp0088536
      Conserved Domains (1) summary
      pfam04923
      Location:126 → 226
      Ninjurin; Ninjurin

    3. NM_206317.2 → NP_996039.1  ninjurin A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996039.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MPN9
      Conserved Domains (1) summary
      pfam04923
      Location:114 → 214
      Ninjurin; Ninjurin

    4. NM_206318.2 → NP_996040.1  ninjurin A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996040.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PHZ8, Q8MPN9, Q8MPP0, Q8SYI2, Q9VTB5
      Conserved Domains (1) summary
      pfam04923
      Location:130 → 230
      Ninjurin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MPP0.1 Q8MPP0

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