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    mad2 mad2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38656, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mad2provided by FlyBase
    Official Full Name
    mad2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035640
    Locus tag
    Dmel_CG17498
    See related
    AllianceGenome:FB:FBgn0035640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17498; Dmel\CG17498; Mad2; MAD2
    Summary
    Involved in chromosome organization; male germ-line stem cell asymmetric division; and regulation of cell cycle process. Located in several cellular components, including nucleus; spindle; and spindle matrix. Is expressed in several structures, including antennal anlage; antennal primordium; ganglia; head epidermis primordium; and mesoderm. Used to study microcephaly. Orthologous to human MAD2L1 (mitotic arrest deficient 2 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mad2 in Genome Data Viewer
    Location:
    64E11-64E12; 3-15 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5812135..5813093, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5805235..5806193, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Tektin C Neighboring gene Ribosomal protein S6 kinase Neighboring gene uncharacterized protein Neighboring gene krishah Neighboring gene vein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct responses to reduplicated chromosomes require distinct Mad2 responses. Stormo BM, et al. Elife, 2016 May 9. PMID 27159240, Free PMC Article
    2. Aneuploidy is Linked to Neurological Phenotypes Through Oxidative Stress. Islam A, et al. J Mol Neurosci, 2024 May 2. PMID 38693434, Free PMC Article
    3. An organelle-exclusion envelope assists mitosis and underlies distinct molecular crowding in the spindle region. Schweizer N, et al. J Cell Biol, 2015 Aug 31. PMID 26304726, Free PMC Article
    4. Kinetochore localized Mad2 and Cdc20 is itself insufficient for triggering the mitotic checkpoint when Mps1 is low in Drosophila melanogaster neuroblasts. Herriott A, et al. Cell Cycle, 2012 Dec 15. PMID 23187806, Free PMC Article
    5. Cenp-meta is required for sustained spindle checkpoint. Rubin T, et al. Biol Open, 2014 May 29. PMID 24876387, Free PMC Article

    See all (132) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kinetochore localized Mad2 and Cdc20 is itself insufficient for triggering the mitotic checkpoint when Mps1 is low in Drosophila melanogaster neuroblasts.
      Title: Kinetochore localized Mad2 and Cdc20 is itself insufficient for triggering the mitotic checkpoint when Mps1 is low in Drosophila melanogaster neuroblasts.
    2. Data show that the Mad2 kinetochore dimerization recruitment mechanism is conserved and that the recruitment of Cdc20 to kinetochores in Drosophila requires BubR1 but not Mad2.
      Title: Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster.
    3. These results strongly suggest that Mad2 is exclusively required to delay progression through early stages of prometaphase so that cells have time to fully engage the spindle assembly checkpoint.
      Title: Mad2-independent spindle assembly checkpoint activation and controlled metaphase-anaphase transition in Drosophila S2 cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male germ-line stem cell asymmetric division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic spindle assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mad2
    Names
    CG17498-PA
    mad2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5812135..5813093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139734.3 → NP_647991.1  mad2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647991.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRQ2
      Related
      FBpp0076819
      Conserved Domains (1) summary
      pfam02301
      Location:13 → 195
      HORMA; HORMA domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRQ2 Q9VRQ2

    Gene LinkOut

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