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    Fdx2 Ferredoxin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38530, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fdx2provided by FlyBase
    Official Full Name
    Ferredoxin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035529
    Locus tag
    Dmel_CG1319
    See related
    AllianceGenome:FB:FBgn0035529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE08888; BcDNA:RH09920; CG1319; Dmel\CG1319; Fdxh2
    Summary
    Predicted to enable electron transfer activity. Involved in positive regulation of ecdysteroid biosynthetic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including adult heart; embryonic anal pad; embryonic epipharynx; embryonic/larval midgut primordium; and gut section. Orthologous to human FDX1 (ferredoxin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fdx2 in Genome Data Viewer
    Location:
    64B1-64B1; 3-12 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4292482..4293432)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4292482..4293432)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Transcription factor IIEbeta Neighboring gene Hexosaminidase 1 Neighboring gene uncharacterized protein Neighboring gene dusky-like Neighboring gene claspin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Frataxin inactivation leads to steroid deficiency in flies and human ovarian cells. Palandri A, et al. Hum Mol Genet, 2015 May 1. PMID 25628335
    2. Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila. Ma Z, et al. Elife, 2024 Sep 10. PMID 39255019, Free PMC Article
    3. Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life Cycle by Controlling Cell Metabolism. Marelja Z, et al. Front Physiol, 2018. PMID 29491838, Free PMC Article
    4. Intestinal response to dietary manganese depletion in Drosophila. Vásquez-Procopio J, et al. Metallomics, 2020 Feb 1. PMID 31799578
    5. The Insect Prothoracic Gland as a Model for Steroid Hormone Biosynthesis and Regulation. Ou Q, et al. Cell Rep, 2016 Jun 28. PMID 27320926, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in P450-containing electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of ecdysteroid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial matrix NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ferredoxin 2
    Names
    CG1319-PB
    Fdx2-PB
    ferredoxin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4292482..4293432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139632.3 → NP_647889.2  ferredoxin 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647889.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SZA8, Q9VZE1
      Conserved Domains (1) summary
      cl00159
      Location:41 → 144
      fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZA8.1 Q8SZA8

    Gene LinkOut

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