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    Cyp4aa1 Cytochrome P450 4aa1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36752, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4aa1provided by FlyBase
    Official Full Name
    Cytochrome P450 4aa1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034053
    Locus tag
    Dmel_CG8302
    See related
    AllianceGenome:FB:FBgn0034053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4aa1; CG8302; Cyp4AA1; CYP4AA1; Dmel\CG8302
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; embryonic hindgut; embryonic/larval hindgut; embryonic/larval proventriculus outer layer; and organism. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4aa1 in Genome Data Viewer
    Location:
    52D3-52D4; 2-76 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15942864..15947266)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11830369..11834771)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene bunker gear Neighboring gene Myelodysplasia/myeloid leukemia factor Neighboring gene uncharacterized protein Neighboring gene Cytochrome c oxidase subunit 6A-like Neighboring gene mir-4919 stem loop Neighboring gene Stretchin-Mlck Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45021

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family. Champagne MB, et al. J Mol Biol, 2000 Jul 21. PMID 10891286
    2. The microevolutionary response to male-limited X-chromosome evolution in Drosophila melanogaster reflects macroevolutionary patterns. Abbott JK, et al. J Evol Biol, 2020 Jun. PMID 32176391
    3. Association of detoxification enzymes with butene-fipronil in larvae and adults of Drosophila melanogaster. Arain MS, et al. Environ Sci Pollut Res Int, 2018 Apr. PMID 29380196
    4. The involvement of cytochrome P450 monooxygenases in methanol elimination in Drosophila melanogaster larvae. Wang SP, et al. Arch Insect Biochem Physiol, 2012 Apr. PMID 22508581
    5. The involvement of several enzymes in methanol detoxification in Drosophila melanogaster adults. Wang SP, et al. Comp Biochem Physiol B Biochem Mol Biol, 2013 Sep. PMID 23751173

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4aa1
    Names
    CG8302-PB
    Cyp4aa1-PB
    cytochrome P450
    NP_611067.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15942864..15947266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137223.3 → NP_611067.2  cytochrome P450 4aa1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611067.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1RKQ6, Q9V7G5
      Conserved Domains (1) summary
      pfam00067
      Location:50 → 475
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V7G5.2 Q9V7G5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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