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    azot ahuizotl [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35751, updated on 9-Dec-2024

    Summary

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    Official Symbol
    azotprovided by FlyBase
    Official Full Name
    ahuizotlprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033238
    Locus tag
    Dmel_CG11165
    See related
    AllianceGenome:FB:FBgn0033238
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Azot; BcDNA:AT10229; BcDNA:AT23738; CBP2; CG11165; Dmel\CG11165
    Summary
    Predicted to enable calcium ion binding activity. Involved in positive regulation of apoptotic process. Predicted to be active in centrosome and cytoplasm. Orthologous to human CALML5 (calmodulin like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See azot in Genome Data Viewer
    Location:
    43F6-43F6; 2-57 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7949839..7950465)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3837344..3837970)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Septin 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Azot expression in the Drosophila gut modulates organismal lifespan. Merino MM. Commun Integr Biol, 2023. PMID 36606245, Free PMC Article
    2. Cell Competition During Growth and Regeneration. Gogna R, et al. Annu Rev Genet, 2015. PMID 26631518
    3. Survival of the Fittest: Essential Roles of Cell Competition in Development, Aging, and Cancer. Merino MM, et al. Trends Cell Biol, 2016 Oct. PMID 27319281
    4. Signaling interactions among neurons impact cell fitness and death in Alzheimer's disease. Yeates C, et al. Neural Regen Res, 2023 Apr. PMID 36204838, Free PMC Article
    5. Culling Less Fit Neurons Protects against Amyloid-β-Induced Brain Damage and Cognitive and Motor Decline. Coelho DS, et al. Cell Rep, 2018 Dec 26. PMID 30590040, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ahuizotl
    Names
    CG11165-PA
    azot-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7949839..7950465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136492.4 → NP_610336.1  ahuizotl [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610336.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q32KC3, Q7K049
      Related
      FBpp0087929
      Conserved Domains (2) summary
      PTZ00184
      Location:1 → 148
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:84 → 146
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K049 Q7K049
    Q8IHA0 Q8IHA0

    Gene LinkOut

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