U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    IA-2 IA-2 protein tyrosine phosphatase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33277, updated on 17-Dec-2024

    Summary

    Official Symbol
    IA-2provided by FlyBase
    Official Full Name
    IA-2 protein tyrosine phosphataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031294
    Locus tag
    Dmel_CG31795
    See related
    AllianceGenome:FB:FBgn0031294
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0153538.69; CG11344; CG31795; CG4355; Dmel\CG31795; ia-2; ia2; IA2; R-PTPX/1A2
    Summary
    Involved in digestive tract development and regulation of secretion. Predicted to be active in secretory granule and synapse. Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; brain; midgut; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to several human genes including PTPRN2 (protein tyrosine phosphatase receptor type N2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IA-2 in Genome Data Viewer
    Location:
    21E3-21E3; 2-1.5 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1008378..1048053, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1008378..1048053, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Transmembrane O-mannosyltransferase targeting cadherins 2 Neighboring gene long non-coding RNA:CR44801 Neighboring gene antisense RNA:CR46486 Neighboring gene uncharacterized protein Neighboring gene germinal nascent polypeptide-associated complex alpha subunit Neighboring gene Star Neighboring gene asteroid

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in digestive tract development PubMed 
    involved_in protein dephosphorylation  
    involved_in regulation of secretion  
    involved_in regulation of secretion PubMed 
    Component Evidence Code Pubs
    is_active_in secretory granule  
    located_in secretory granule  
    is_active_in synapse  

    General protein information

    Preferred Names
    IA-2 protein tyrosine phosphatase
    Names
    CG31795-PC
    CG31795-PD
    CG31795-PE
    IA-2 ortholog
    IA-2-PC
    IA-2-PD
    IA-2-PE
    ia2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1008378..1048053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164401.5 → NP_722672.3  IA-2 protein tyrosine phosphatase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722672.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E11, Q7YTY8
      Conserved Domains (3) summary
      smart00194
      Location:947 → 1207
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:982 → 1207
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam11548
      Location:695 → 782
      Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    2. NM_134718.6 → NP_608562.4  IA-2 protein tyrosine phosphatase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608562.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YTY8, Q9VPV8
      Conserved Domains (3) summary
      smart00194
      Location:960 → 1220
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:995 → 1220
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam11548
      Location:708 → 795
      Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    3. NM_001272922.1 → NP_001259851.1  IA-2 protein tyrosine phosphatase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259851.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PAZ4, Q7YTY8
      Conserved Domains (3) summary
      smart00194
      Location:959 → 1219
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:994 → 1219
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam11548
      Location:707 → 794
      Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    External link. Please review our privacy policy.