phtm phantom [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: phtmprovided by FlyBase
Official Full Name: phantomprovided by FlyBase
Primary source: FLYBASE:FBgn0004959
Locus tag: Dmel_CG6578
See related: AllianceGenome:FB:FBgn0004959
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 306a1; CG6578; Cyp306a1; CYP306A1; Cyp306a1-Dm; Dmel\CG6578; exo; phm; Phm; ptm
Summary: Enables ecdysteroid 25-hydroxylase activity. Involved in border follicle cell migration; ecdysone biosynthetic process; and embryonic development via the syncytial blastoderm. Located in endoplasmic reticulum. Is expressed in several structures, including antennal anlage; epithelium; head epidermis primordium; mesoderm; and neurohemal organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); drug dependence (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to several human genes including CYP2R1 (cytochrome P450 family 2 subfamily R member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18685766..18688433)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (18579799..18582466)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ecdysteroid 25-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables steroid hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ecdysone biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ecdysone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic development via the syncytial blastoderm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info