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    CG3842 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31576, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG3842provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029866
    Locus tag
    Dmel_CG3842
    See related
    AllianceGenome:FB:FBgn0029866
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3842; lincRNA.959
    Summary
    Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in retinal metabolic process. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; embryonic anal pad; embryonic dorsal epidermis; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 13 and Leber hereditary optic neuropathy. Orthologous to human RDH11 (retinol dehydrogenase 11) and RDH12 (retinol dehydrogenase 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3842 in Genome Data Viewer
    Location:
    5F2-5F2; 1-16 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6337762..6343731)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6231795..6237764)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B16.6 subunit Neighboring gene knockdown

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster. Belyaeva OV, et al. Biochim Biophys Acta, 2009 Oct. PMID 19520149, Free PMC Article
    2. Transcript level is a key factor affecting RNAi efficiency. Chen J, et al. Pestic Biochem Physiol, 2021 Jul. PMID 34119217
    3. Metabolic disruption in Drosophila bang-sensitive seizure mutants. Fergestad T, et al. Genetics, 2006 Jul. PMID 16648587, Free PMC Article
    4. Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes. Yu J, et al. Development, 2016 Aug 15. PMID 27471256
    5. Genome-wide transcription profile of field- and laboratory-selected dichlorodiphenyltrichloroethane (DDT)-resistant Drosophila. Pedra JH, et al. Proc Natl Acad Sci U S A, 2004 May 4. PMID 15118106, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables all-trans-retinol dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in retinal metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3842-PA
    CG3842-PB
    CG3842-PC
    CG3842-PD
    NP_001259270.1
    NP_001259271.1
    NP_572316.1
    NP_996356.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6337762..6343731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272342.2 → NP_001259271.1  uncharacterized protein Dmel_CG3842, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259271.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM5, Q9W404
      Conserved Domains (2) summary
      COG1028
      Location:71 → 319
      FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl21454
      Location:74 → 347
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001272341.1 → NP_001259270.1  uncharacterized protein Dmel_CG3842, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259270.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM5, Q9W404
      Conserved Domains (2) summary
      COG1028
      Location:71 → 319
      FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl21454
      Location:74 → 347
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_132088.3 → NP_572316.1  uncharacterized protein Dmel_CG3842, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572316.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM5, Q9W404
      Related
      FBpp0070868
      Conserved Domains (2) summary
      COG1028
      Location:71 → 319
      FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl21454
      Location:74 → 347
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. NM_206633.3 → NP_996356.1  uncharacterized protein Dmel_CG3842, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996356.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNM5, Q9W404
      Conserved Domains (2) summary
      COG1028
      Location:71 → 319
      FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl21454
      Location:74 → 347
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W404 Q9W404

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