U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Coa8 Cytochrome c oxidase assembly factor 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31148, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Coa8provided by FlyBase
    Official Full Name
    Cytochrome c oxidase assembly factor 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0029594
    Locus tag
    Dmel_CG14806
    See related
    AllianceGenome:FB:FBgn0029594
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Apop1; CG14806; dCOA8; Dmel\CG14806
    Summary
    Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial membrane. Used to study mitochondrial complex IV deficiency nuclear type 17. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 17. Orthologous to human COA8 (cytochrome c oxidase assembly factor 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Coa8 in Genome Data Viewer
    Location:
    2B14-2B14; 1-0.2 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1880282..1881432)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1774315..1775465)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting 26 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene trithorax-related Neighboring gene mitochondrial ribosomal protein L16 Neighboring gene armadillo Neighboring gene antisense RNA:CR45929 Neighboring gene Lipid droplet assembly factor 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Knockdown of APOPT1/COA8 Causes Cytochrome c Oxidase Deficiency, Neuromuscular Impairment, and Reduced Resistance to Oxidative Stress in Drosophila melanogaster. Brischigliaro M, et al. Front Physiol, 2019. PMID 31555154, Free PMC Article
    2. Measurement of mitochondrial respiratory chain enzymatic activities in Drosophila melanogaster samples. Brischigliaro M, et al. STAR Protoc, 2022 Jun 17. PMID 35479112, Free PMC Article
    3. Structural rather than catalytic role for mitochondrial respiratory chain supercomplexes. Brischigliaro M, et al. Elife, 2023 Oct 12. PMID 37823874, Free PMC Article
    4. Mitochondrial Cytochrome c Oxidase Defects Alter Cellular Homeostasis of Transition Metals. Brischigliaro M, et al. Front Cell Dev Biol, 2022. PMID 35663391, Free PMC Article
    5. Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation. Meiklejohn CD, et al. PLoS Biol, 2011 Aug. PMID 21857805, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    NOT involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in matrix side of mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cytochrome c oxidase assembly factor 8
    Names
    CG14806-PA
    CG14806-PB
    Coa8-PA
    Coa8-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1880282..1881432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130600.2 → NP_569956.1  cytochrome c oxidase assembly factor 8, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569956.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W549
      UniProtKB/TrEMBL
      C7LAA6, M9PG94
      Related
      FBpp0070300
      Conserved Domains (1) summary
      pfam10231
      Location:52 → 169
      DUF2315; Uncharacterized conserved protein (DUF2315)

    2. NM_001272218.1 → NP_001259147.1  cytochrome c oxidase assembly factor 8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259147.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W549
      UniProtKB/TrEMBL
      C7LAA6, M9PG94
      Conserved Domains (1) summary
      pfam10231
      Location:52 → 169
      DUF2315; Uncharacterized conserved protein (DUF2315)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PG94 M9PG94
    Q9W549.1 Q9W549

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools