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    Adk3 Adenosine kinase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44750, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adk3provided by FlyBase
    Official Full Name
    Adenosine kinase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0026602
    Locus tag
    Dmel_CG1851
    See related
    AllianceGenome:FB:FBgn0026602
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Adk43A; Ady; ady43A; Ady43A; CG1851; DmAdk3; Dmel\CG1851
    Summary
    Predicted to enable adenosine kinase activity. Predicted to be involved in purine nucleobase metabolic process. Predicted to be active in cytosol and nucleus. Is expressed in mesoderm anlage and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Adk3 in Genome Data Viewer
    Location:
    43A1-43A2; 2-55 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7243024..7245776, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3130529..3133281, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene prickle Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 43a Neighboring gene long non-coding RNA:CR45280 Neighboring gene Growth arrest and DNA damage-inducible 45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A regulatory code for neurogenic gene expression in the Drosophila embryo. Markstein M, et al. Development, 2004 May. PMID 15128669
    2. Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila. Patterson RA, et al. PLoS One, 2013. PMID 23637905, Free PMC Article
    3. The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs. Gubb D, et al. Genes Dev, 1999 Sep 1. PMID 10485852, Free PMC Article
    4. Inbreeding by environmental interactions affect gene expression in Drosophila melanogaster. Kristensen TN, et al. Genetics, 2006 Jul. PMID 16624914, Free PMC Article
    5. Differential response of Drosophila cell lines to extracellular adenosine. Fleischmannova J, et al. Insect Biochem Mol Biol, 2012 May. PMID 22266077

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in purine nucleobase metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenosine kinase 3
    Names
    Adk3-PA
    Ady43A
    CG1851-PA
    NP_651995.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7243024..7245776 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143738.4 → NP_651995.1  adenosine kinase 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651995.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JWW6
      Related
      FBpp0088121
      Conserved Domains (2) summary
      cd01168
      Location:28 → 366
      adenosine_kinase; Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine ...
      PTZ00247
      Location:28 → 366
      PTZ00247; adenosine kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JWW6 Q7JWW6

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