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    PIG-K Phosphatidylinositol glycan anchor biosynthesis class K [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31163, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIG-Kprovided by FlyBase
    Official Full Name
    Phosphatidylinositol glycan anchor biosynthesis class Kprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023545
    Locus tag
    Dmel_CG4406
    See related
    AllianceGenome:FB:FBgn0023545
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg4406; CG4406; Dmel\CG4406; EG:133E12.3; PIGK
    Summary
    Predicted to enable GPI-anchor transamidase activity. Predicted to be involved in attachment of GPI anchor to protein. Part of GPI-anchor transamidase complex. Is active in endoplasmic reticulum. Is expressed in adult head and organism. Orthologous to human PIGK (phosphatidylinositol glycan anchor biosynthesis class K). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PIG-K in Genome Data Viewer
    Location:
    2C1-2C1; 1-0.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2007911..2009364, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1901944..1903397, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Hormone receptor 4 Neighboring gene pseudo Neighboring gene long non-coding RNA:CR45478 Neighboring gene mir-2496 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stability of the transamidase complex catalyzing GPI anchoring of proteins. Kawaguchi K, et al. Biochem Biophys Res Commun, 2019 May 7. PMID 30914202
    2. Subunits of the GPI transamidase complex localize to the endoplasmic reticulum and nuclear envelope in Drosophila. Kawaguchi K, et al. FEBS Lett, 2021 Apr. PMID 33496978
    3. Drosophila Trf4-1 involves in mRNA and primary miRNA transcription. Liu Y, et al. Biochem Biophys Res Commun, 2019 Apr 16. PMID 30837153
    4. Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila. Hallacli E, et al. Mol Cell, 2012 Nov 30. PMID 23084835
    5. Gain-of-function screen identifies a role of the Sec61alpha translocon in Drosophila postmitotic neurotoxicity. Kanuka H, et al. Biochim Biophys Acta, 2005 Nov 30. PMID 16243437

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GPI-anchor transamidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GPI-anchor transamidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GPI-anchor transamidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of GPI anchor to protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of GPI anchor to protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GPI-anchor transamidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of GPI-anchor transamidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of GPI-anchor transamidase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol glycan anchor biosynthesis class K
    Names
    CG4406-PA
    PIG-K-PA
    NP_569968.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2007911..2009364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130612.4 → NP_569968.2  phosphatidylinositol glycan anchor biosynthesis class K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569968.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46047, Q8T4E1, Q9W538
      Related
      FBpp0070333
      Conserved Domains (1) summary
      cl00042
      Location:35 → 325
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T4E1.1 Q8T4E1

    Gene LinkOut

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