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    Sr-CI Scavenger receptor class C, type I [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33621, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Sr-CIprovided by FlyBase
    Official Full Name
    Scavenger receptor class C, type Iprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014033
    Locus tag
    Dmel_CG4099
    See related
    AllianceGenome:FB:FBgn0014033
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4099; CT9876; D-SR-CI; Dmel\CG4099; dScR-I; dSR-C1; dSR-CI; DSR-CI; dSRC-I; ScrCI; Sr-C1; SR-C1; SR-CI; Sr-Cl; Sr-CL; SrCl
    Summary
    Enables scavenger receptor activity. Involved in endocytosis. Located in plasma membrane. Is expressed in adult head; embryonic/larval hemocyte; embryonic/larval plasmatocyte; head mesoderm; and plasmatocyte primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sr-CI in Genome Data Viewer
    Location:
    24D6-24D6; 2-11 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4121702..4124153)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4121702..4124153)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene echinoid Neighboring gene antisense RNA:CR44984 Neighboring gene Scavenger receptor class C, type III Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 24a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression cloning of dSR-CI, a class C macrophage-specific scavenger receptor from Drosophila melanogaster. Pearson A, et al. Proc Natl Acad Sci U S A, 1995 Apr 25. PMID 7732030, Free PMC Article
    2. Recognizing death: the phagocytosis of apoptotic cells. Platt N, et al. Trends Cell Biol, 1998 Sep. PMID 9728398
    3. Phagocytosis of apoptotic cells in mammals, caenorhabditis elegans and Drosophila melanogaster: molecular mechanisms and physiological consequences. Franc NC. Front Biosci, 2002 May 1. PMID 11991836
    4. A phagocytic route for uptake of double-stranded RNA in RNAi. Rocha JJ, et al. PLoS One, 2011 Apr 29. PMID 21559499, Free PMC Article
    5. Innate recognition systems in insect immunity and development: new approaches in Drosophila. Franc NC, et al. Microbes Infect, 2000 Mar. PMID 10758400

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila S2 cells internalize double-stranded RNA by scavenger receptor-mediated endocytosis
      Title: Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells.
    2. Hmu, Sr-CI/Sr-CIII, and Tehao have polymorphic sites in nearly perfect linkage disequilibrium
      Title: Linkage disequilibrium and recent selection at three immunity receptor loci in Drosophila simulans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables polysaccharide binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables scavenger receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables scavenger receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phagocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to bacterium TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    scavenger receptor class C, type I
    Names
    CG4099-PA
    CG4099-PB
    Sr-CI-PA
    Sr-CI-PB
    scavenger receptor
    scavenger receptor C, type I
    scavenger receptor class C
    scavenger receptor class C, type 1
    scavenger receptor class V, type 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4121702..4124153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298670.1 → NP_001285599.1  scavenger receptor class C, type I, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285599.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5ELT4, Q5ELU4, Q5ELV0, Q9V3H7
      Conserved Domains (4) summary
      cd06263
      Location:136 → 308
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00032
      Location:22 → 72
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      smart00137
      Location:131 → 308
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cl02508
      Location:335 → 385
      Somatomedin_B; Somatomedin B domain

    2. NM_057754.3 → NP_477102.1  scavenger receptor class C, type I, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477102.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5ELT4, Q5ELU4, Q5ELV0, Q9V3H7
      Related
      FBpp0077156
      Conserved Domains (4) summary
      cd06263
      Location:136 → 308
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00032
      Location:22 → 72
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      smart00137
      Location:131 → 308
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cl02508
      Location:335 → 385
      Somatomedin_B; Somatomedin B domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24017 Q24017
    Q58SM0 Q58SM0
    Q58SM1 Q58SM1
    Q58SM2 Q58SM2
    Q58SM3 Q58SM3
    Q58SM4 Q58SM4
    Q58SM6 Q58SM6
    Q58SM7 Q58SM7
    Q5ELR5 Q5ELR5
    Q5ELR7 Q5ELR7
    Q5ELR9 Q5ELR9
    Q5ELS1 Q5ELS1
    Q5ELS3 Q5ELS3
    Q5ELS5 Q5ELS5
    Q5ELS7 Q5ELS7
    Q5ELS8 Q5ELS8
    Q5ELT0 Q5ELT0
    Q5ELT4 Q5ELT4
    Q5ELT8 Q5ELT8
    Q5ELU0 Q5ELU0
    Q5ELU2 Q5ELU2
    Q5ELU4 Q5ELU4
    Q5ELU8 Q5ELU8
    Q5ELV0 Q5ELV0
    Q6V6S0 Q6V6S0
    Q6V6S1 Q6V6S1
    Q6V6S2 Q6V6S2
    Q6V6S4 Q6V6S4
    Q9V3H7 Q9V3H7

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