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    ERp44 Endoplasmic reticulum protein 44 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32588, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ERp44provided by FlyBase
    Official Full Name
    Endoplasmic reticulum protein 44provided by FlyBase
    Primary source
    FLYBASE:FBgn0030734
    Locus tag
    Dmel_CG9911
    See related
    AllianceGenome:FB:FBgn0030734
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9911; CG9912; Dmel\CG9911; LD41494p
    Summary
    Predicted to enable protein disulfide isomerase activity. Predicted to be involved in protein folding. Located in endomembrane system. Is expressed in adult head and adult heart. Orthologous to human ERP44 (endoplasmic reticulum protein 44). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ERp44 in Genome Data Viewer
    Location:
    14B9-14B9; 1-53 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16293853..16297718, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16187886..16191751, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ubiquinol-cytochrome c reductase 14 kDa subunit Neighboring gene cabeza Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45485 Neighboring gene beta Hydroxy acid dehydrogenase 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ERp44/CG9911 promotes fat storage in Drosophila adipocytes by regulating ER Ca(2+) homeostasis. Bi Y, et al. Aging (Albany NY), 2021 May 24. PMID 34031268, Free PMC Article
    2. The thioredoxin-like fold: hidden domains in protein disulfide isomerases and other chaperone proteins. Clissold PM, et al. Bioessays, 2003 Jun. PMID 12766950
    3. Cis-regulatory variation is typically polyallelic in Drosophila. Gruber JD, et al. Genetics, 2009 Feb. PMID 19064705, Free PMC Article
    4. EDEM Function in ERAD Protects against Chronic ER Proteinopathy and Age-Related Physiological Decline in Drosophila. Sekiya M, et al. Dev Cell, 2017 Jun 19. PMID 28633019, Free PMC Article
    5. Regulation and biological function of metal ions in Drosophila. Missirlis F. Curr Opin Insect Sci, 2021 Oct. PMID 33581350

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum protein 44
    Names
    CG9911-PA
    CG9911-PB
    CG9911-PC
    CG9911-PD
    ERp44-PA
    ERp44-PB
    ERp44-PC
    ERp44-PD
    NP_573111.1
    NP_727947.1
    NP_727948.1
    NP_727949.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16293853..16297718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167495.3 → NP_727948.1  endoplasmic reticulum protein 44, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727948.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TL8
      Related
      FBpp0074020
      Conserved Domains (4) summary
      cd02996
      Location:33 → 140
      PDI_a_ERp44; PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily; ERp44 is an ER-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain, similar to that of PDIa, with a CXFS motif followed by ...
      cd03070
      Location:148 → 241
      PDI_b_ERp44; PDIb family, ERp44 subfamily, first redox inactive TRX-like domain b; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif followed ...
      cd03072
      Location:252 → 362
      PDI_b'_ERp44; PDIb' family, ERp44 subfamily, second redox inactive TRX-like domain b'; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif ...
      pfam13848
      Location:171 → 357
      Thioredoxin_6; Thioredoxin-like domain

    2. NM_167494.3 → NP_727947.1  endoplasmic reticulum protein 44, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727947.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TL8
      Related
      FBpp0074021
      Conserved Domains (4) summary
      cd02996
      Location:33 → 140
      PDI_a_ERp44; PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily; ERp44 is an ER-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain, similar to that of PDIa, with a CXFS motif followed by ...
      cd03070
      Location:148 → 241
      PDI_b_ERp44; PDIb family, ERp44 subfamily, first redox inactive TRX-like domain b; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif followed ...
      cd03072
      Location:252 → 362
      PDI_b'_ERp44; PDIb' family, ERp44 subfamily, second redox inactive TRX-like domain b'; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif ...
      pfam13848
      Location:171 → 357
      Thioredoxin_6; Thioredoxin-like domain

    3. NM_132883.4 → NP_573111.1  endoplasmic reticulum protein 44, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573111.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TL8
      Related
      FBpp0074022
      Conserved Domains (4) summary
      cd02996
      Location:33 → 140
      PDI_a_ERp44; PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily; ERp44 is an ER-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain, similar to that of PDIa, with a CXFS motif followed by ...
      cd03070
      Location:148 → 241
      PDI_b_ERp44; PDIb family, ERp44 subfamily, first redox inactive TRX-like domain b; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif followed ...
      cd03072
      Location:252 → 362
      PDI_b'_ERp44; PDIb' family, ERp44 subfamily, second redox inactive TRX-like domain b'; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif ...
      pfam13848
      Location:171 → 357
      Thioredoxin_6; Thioredoxin-like domain

    4. NM_167496.3 → NP_727949.1  endoplasmic reticulum protein 44, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727949.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXI3
      Related
      FBpp0074023
      Conserved Domains (4) summary
      cd02996
      Location:1 → 103
      PDI_a_ERp44; PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily; ERp44 is an ER-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain, similar to that of PDIa, with a CXFS motif followed by ...
      cd03070
      Location:111 → 204
      PDI_b_ERp44; PDIb family, ERp44 subfamily, first redox inactive TRX-like domain b; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif followed ...
      cd03072
      Location:215 → 325
      PDI_b'_ERp44; PDIb' family, ERp44 subfamily, second redox inactive TRX-like domain b'; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif ...
      pfam13848
      Location:134 → 320
      Thioredoxin_6; Thioredoxin-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TL8 Q95TL8
    Q9VXI3 Q9VXI3

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