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    Ppn Papilin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43872, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Ppnprovided by FlyBase
    Official Full Name
    Papilinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003137
    Locus tag
    Dmel_CG33103
    See related
    AllianceGenome:FB:FBgn0003137
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1540; CG18436; CG33103; CT3186; CT41988; Dmel\CG33103; ppl; ppn
    Summary
    An extracellular matrix structural constituent. Involved in extracellular matrix organization. Located in basement membrane. Is expressed in several structures, including adult head; adult heart; epithelial furrow; gut section; and proventriculus primordium. Orthologous to human PAPLN (papilin, proteoglycan like sulfated glycoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ppn in Genome Data Viewer
    Location:
    98D3-98D4; 3-96 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28520665..28540324, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24346387..24366046, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Dynein heavy chain at 89D Neighboring gene uncharacterized protein Neighboring gene mitochondrial translation initiation factor 2 Neighboring gene fork head

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Papilin: a Drosophila proteoglycan-like sulfated glycoprotein from basement membranes. Campbell AG, et al. J Biol Chem, 1987 Dec 25. PMID 3320045
    2. Alternative splicing of papilin and the diversity of Drosophila extracellular matrix during embryonic morphogenesis. Kramerova IA, et al. Dev Dyn, 2003 Apr. PMID 12666201
    3. Secreted ADAMTS-like proteins as regulators of connective tissue function. Taye N, et al. Am J Physiol Cell Physiol, 2024 Mar 1. PMID 38284126
    4. Nascent-seq indicates widespread cotranscriptional pre-mRNA splicing in Drosophila. Khodor YL, et al. Genes Dev, 2011 Dec 1. PMID 22156210, Free PMC Article
    5. The expression of MDP-1, a component of Drosophila embryonic basement membranes, is modulated by apoptotic cell death. Hortsch M, et al. Int J Dev Biol, 1998 Jan. PMID 9496784

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila, which has a compact genome, expresses three splice variants of papilin during embryogenesis in developmentally defined patterns.
      Title: Alternative splicing of papilin and the diversity of Drosophila extracellular matrix during embryonic morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    papilin
    Names
    CG33103-PC
    CG33103-PE
    CG33103-PF
    CG33103-PG
    Ppn-PC
    Ppn-PE
    Ppn-PF
    Ppn-PG
    lacunin
    lacunin-like
    papilin precursor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28520665..28540324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170289.2 → NP_001163760.1  papilin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163760.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q868Z9
      Conserved Domains (8) summary
      smart00209
      Location:60 → 111
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:2042 → 2117
      IG_like; Immunoglobulin like
      pfam00014
      Location:1670 → 1721
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00090
      Location:645 → 693
      TSP_1; Thrombospondin type 1 domain
      pfam00095
      Location:1872 → 1912
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
      pfam05986
      Location:214 → 329
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:2127 → 2159
      PLAC; PLAC (protease and lacunin) domain
      cl11960
      Location:1936 → 2025
      Ig; Immunoglobulin domain

    2. NM_001170290.2 → NP_001163761.1  papilin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163761.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q868Z9
      Conserved Domains (10) summary
      cd00096
      Location:2579 → 2644
      Ig; Immunoglobulin domain
      smart00209
      Location:60 → 111
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:2709 → 2784
      IG_like; Immunoglobulin like
      cd00109
      Location:2014 → 2064
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:1670 → 1721
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00090
      Location:645 → 693
      TSP_1; Thrombospondin type 1 domain
      pfam00095
      Location:2400 → 2440
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
      pfam05986
      Location:214 → 329
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:2794 → 2826
      PLAC; PLAC (protease and lacunin) domain
      cl11960
      Location:2464 → 2553
      Ig; Immunoglobulin domain

    3. NM_176574.3 → NP_788751.2  papilin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788751.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q868Z9
      Conserved Domains (10) summary
      cd00096
      Location:2514 → 2579
      Ig; Immunoglobulin domain
      smart00209
      Location:60 → 111
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:2644 → 2719
      IG_like; Immunoglobulin like
      cd00109
      Location:2071 → 2121
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:1670 → 1721
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00090
      Location:645 → 693
      TSP_1; Thrombospondin type 1 domain
      pfam00095
      Location:2335 → 2375
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
      pfam05986
      Location:214 → 329
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:2729 → 2761
      PLAC; PLAC (protease and lacunin) domain
      cl11960
      Location:2399 → 2488
      Ig; Immunoglobulin domain

    4. NM_176575.3 → NP_788752.2  papilin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788752.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JJ05, E1JJ06, Q6NP04, Q7KRX2, Q868Z9, Q869A0, Q9GQR0, Q9VAV3, Q9VAV4
      Conserved Domains (10) summary
      cd00096
      Location:2636 → 2701
      Ig; Immunoglobulin domain
      smart00209
      Location:60 → 111
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:2766 → 2841
      IG_like; Immunoglobulin like
      cd00109
      Location:2071 → 2121
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:1670 → 1721
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00090
      Location:645 → 693
      TSP_1; Thrombospondin type 1 domain
      pfam00095
      Location:2457 → 2497
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
      pfam05986
      Location:214 → 329
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:2851 → 2883
      PLAC; PLAC (protease and lacunin) domain
      cl11960
      Location:2521 → 2610
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q868Z9.2 Q868Z9
    Q95SR4 Q95SR4

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