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    Tina-1 Troponin C-akin-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37989, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tina-1provided by FlyBase
    Official Full Name
    Troponin C-akin-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035083
    Locus tag
    Dmel_CG2803
    See related
    AllianceGenome:FB:FBgn0035083
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GM14784; CG2803; Dmel\CG2803
    Summary
    Predicted to enable gamma-glutamylaminecyclotransferase activity. Predicted to be involved in heart development. Predicted to be active in cytosol. Is expressed in adult head; adult heart; and embryonic/larval heart. Orthologous to human GGACT (gamma-glutamylamine cyclotransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tina-1 in Genome Data Viewer
    Location:
    60E5-60E8; 2-107 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24940625..24942413, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20828148..20829936, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel. Lovato TL, et al. Development, 2002 Nov. PMID 12397110
    2. Second chromosome genes required for heart development in Drosophila melanogaster. Tao Y, et al. Genesis, 2007 Oct. PMID 17941041
    3. Establishing A-P polarity in the embryonic heart tube: a conserved function of Hox genes in Drosophila and vertebrates? Lo PC, et al. Trends Cardiovasc Med, 2003 Jul. PMID 12837580
    4. Microarray analysis of the gene expression profiles of SL2 cells stimulated by LPS/PGN and curdlan. Jin LH, et al. Mol Cells, 2008 Jun 30. PMID 18460901
    5. Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase. Chen CL, et al. Proc Natl Acad Sci U S A, 2015 Sep 29. PMID 26362788, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables gamma-glutamylaminecyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables gamma-glutamylaminecyclotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    troponin C-akin-1
    Names
    CG2803-PA
    CG2803-PB
    Tina-1-PA
    Tina-1-PB
    NP_001033974.1
    NP_611983.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24940625..24942413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138139.4 → NP_611983.2  troponin C-akin-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611983.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95T30, Q9W0Y1
      Related
      FBpp0072317
      Conserved Domains (1) summary
      pfam06094
      Location:14 → 130
      GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

    2. NM_001038885.2 → NP_001033974.1  troponin C-akin-1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033974.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PE12
      Conserved Domains (1) summary
      cl22886
      Location:1 → 38
      GGCT_like; GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2PE12 Q2PE12
    Q9W0Y1.1 Q9W0Y1

    Gene LinkOut

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