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    CG11807 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36683, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11807provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033996
    Locus tag
    Dmel_CG11807
    See related
    AllianceGenome:FB:FBgn0033996
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT14564; Dmel\CG11807
    Summary
    Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be active in cytoplasm. Is expressed in organism. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11807 in Genome Data Viewer
    Location:
    51E5-51E5; 2-74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15201253..15204466)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11088758..11091971)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Golgi pH Regulator Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 51a Neighboring gene relative of woc Neighboring gene Ionotropic receptor 51b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation. O'Farrell F, et al. Nat Cell Biol, 2017 Dec. PMID 29084199
    2. Differential evolutionary wiring of the tyrosine kinase Btk. Nawaz HM, et al. PLoS One, 2012. PMID 22574122, Free PMC Article
    3. A genome engineering resource to uncover principles of cellular organization and tissue architecture by lipid signaling. Trivedi D, et al. Elife, 2020 Dec 15. PMID 33320085, Free PMC Article
    4. Phosphoinositide signalling in Drosophila. Balakrishnan SS, et al. Biochim Biophys Acta, 2015 Jun. PMID 25449646
    5. Comparative exploration of mammalian deafness gene homologues in the Drosophila auditory organ shows genetic correlation between insect and vertebrate hearing. Sutton DC, et al. PLoS One, 2024. PMID 38412189, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11807-PA
    CG11807-PB
    CG11807-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15201253..15204466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274061.2 → NP_001260990.1  uncharacterized protein Dmel_CG11807, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260990.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K490
      Conserved Domains (4) summary
      cd06875
      Location:8 → 126
      PX_IRAS; The phosphoinositide binding Phox Homology domain of the Imidazoline Receptor Antisera-Selected
      sd00033
      Location:315 → 336
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:381 → 422
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:335 → 414
      LRR_8; Leucine rich repeat

    2. NM_001274062.2 → NP_001260991.1  uncharacterized protein Dmel_CG11807, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260991.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K490
      Conserved Domains (4) summary
      cd06875
      Location:8 → 126
      PX_IRAS; The phosphoinositide binding Phox Homology domain of the Imidazoline Receptor Antisera-Selected
      sd00033
      Location:315 → 336
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:381 → 422
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:335 → 414
      LRR_8; Leucine rich repeat

    3. NM_137173.5 → NP_611017.1  uncharacterized protein Dmel_CG11807, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K490
      Related
      FBpp0086496
      Conserved Domains (4) summary
      cd06875
      Location:8 → 126
      PX_IRAS; The phosphoinositide binding Phox Homology domain of the Imidazoline Receptor Antisera-Selected
      sd00033
      Location:315 → 336
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:381 → 422
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:335 → 414
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K490 Q7K490

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