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    CG5618 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40241, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5618provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036975
    Locus tag
    Dmel_CG5618
    See related
    AllianceGenome:FB:FBgn0036975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5618
    Summary
    Predicted to enable glutamate decarboxylase activity. Predicted to be involved in carboxylic acid metabolic process. Predicted to be active in cytoplasm. Is expressed in embryonic small intestine; embryonic/larval fat body; embryonic/larval midgut; embryonic/larval posterior spiracle; and embryonic/larval tracheal dorsal trunk. Orthologous to human GADL1 (glutamate decarboxylase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5618 in Genome Data Viewer
    Location:
    77B5-77B5; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20353449..20356632)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20346549..20349732)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Serpin 77Bc Neighboring gene pseudo Neighboring gene Retinoblastoma binding protein 5 Neighboring gene eukaryotic translation release factor 1 Neighboring gene kin17 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide transcriptional orchestration of circadian rhythms in Drosophila. Ueda HR, et al. J Biol Chem, 2002 Apr 19. PMID 11854264
    2. Mating alters gene expression patterns in Drosophila melanogaster male heads. Ellis LL, et al. BMC Genomics, 2010 Oct 11. PMID 20937114, Free PMC Article
    3. Characteristics of genes up-regulated and down-regulated after 24 h starvation in the head of Drosophila. Fujikawa K, et al. Gene, 2009 Oct 1. PMID 19573582
    4. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. Palu RA, et al. PLoS Genet, 2016 Apr. PMID 27058248, Free PMC Article
    5. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbon-carbon lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate decarboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5618-PA
    CG5618-PD
    CG5618-PE
    NP_001262106.1
    NP_649211.1
    NP_996124.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20353449..20356632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275177.1 → NP_001262106.1  uncharacterized protein Dmel_CG5618, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262106.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG67
      Conserved Domains (1) summary
      cl18945
      Location:1 → 340
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    2. NM_140954.4 → NP_649211.1  uncharacterized protein Dmel_CG5618, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649211.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPH6
      Related
      FBpp0077837
      Conserved Domains (1) summary
      cl18945
      Location:97 → 504
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    3. NM_206402.2 → NP_996124.1  uncharacterized protein Dmel_CG5618, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996124.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PG67
      Conserved Domains (1) summary
      cl18945
      Location:1 → 340
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PG67 M9PG67
    Q8IGZ7 Q8IGZ7
    Q9VPH6 Q9VPH6

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