Fic Fic domain-containing protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ficprovided by FlyBase
Official Full Name: Fic domain-containing proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0263278
Locus tag: Dmel_CG9523
See related: AllianceGenome:FB:FBgn0263278
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9523; Dmel\CG9523; fic; l(2)k11101
Summary: Enables several functions, including AMPylase activity; Hsp70 protein binding activity; and protein adenylylhydrolase activity. Involved in several processes, including detection of light stimulus involved in visual perception; protein adenylylation; and protein deadenylylation. Located in plasma membrane. Is expressed in adult head; adult lamina epithelial glial cell; epithelial glial cell; and organism. Orthologous to human FICD (FIC domain protein adenylyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 26D1-26D1; 2-20 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6424336..6426371)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6424336..6426371)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Fic causes progressive neurodegeneration in a Drosophila model of hereditary spastic paraplegia.
Title: Loss of Fic causes progressive neurodegeneration in a Drosophila model of hereditary spastic paraplegia.
Fic-mediated AMPylation tempers the unfolded protein response during physiological stress.
Title: Fic-mediated AMPylation tempers the unfolded protein response during physiological stress.
These findings show that Fic-mediated AMPylation of BiP is required for neurons to adapt to transient stress demands.
Title: Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration.
Data (including data from studies using transgenic animals) suggest that dual enzymatic activity of Fic is, in part, regulated by Fic dimerization, as loss of this dimerization increases AMPylation and reduces deAMPylation of BiP/Grp78. (Fic = Fic domain-containing protein; BiP/Grp78 = molecular chaperone BiP)
Title: Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies.
The inactive conformation of BiP is the preferred substrate for dFic.
Title: Unfolded protein response-regulated Drosophila Fic (dFic) protein reversibly AMPylates BiP chaperone during endoplasmic reticulum homeostasis.
Our data are consistent with the idea that Fic's enzymatic activity is involved in the regulation of the distribution of the visual neurotransmitter histamine
Title: Visual neurotransmission in Drosophila requires expression of Fic in glial capitate projections.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables AMPylase activity	IDA Inferred from Direct Assay more info	PubMed
enables Hsp70 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein adenylylhydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-folding chaperone binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in detection of light stimulus involved in visual perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in histamine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein adenylylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deadenylylation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
involved_in visual behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Fic domain-containing protein

Names: CG9523-PA; Fic-PA; lethal (2) k11101

NP_609026.1

EC 2.7.7.108

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

6424336..6426371

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_135182.2 → NP_609026.1 Fic domain-containing protein [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609026.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8SWV6, Q9VMD8

Related

FBpp0078887

Conserved Domains (4) summary

COG3177
Location:215 → 442

COG3177; Fic family protein [Transcription]

sd00006
Location:122 → 146

TPR; TPR repeat [structural motif]

pfam02661
Location:297 → 393

Fic; Fic/DOC family

pfam13414
Location:117 → 184

TPR_11; TPR repeat