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    FZD3 frizzled class receptor 3 [ Homo sapiens (human) ]

    Gene ID: 7976, updated on 5-Jan-2025

    Summary

    Official Symbol
    FZD3provided by HGNC
    Official Full Name
    frizzled class receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:4041
    See related
    Ensembl:ENSG00000104290 MIM:606143; AllianceGenome:HGNC:4041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Fz-3
    Summary
    This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]
    Expression
    Broad expression in brain (RPKM 6.0), ovary (RPKM 2.6) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FZD3 in Genome Data Viewer
    Location:
    8p21.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (28494212..28574258)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (28772375..28852426)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (28351729..28431775)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr8:28277089-28277305 Neighboring gene RNA, U6 small nuclear 178, pseudogene Neighboring gene F-box protein 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19060 Neighboring gene VISTA enhancer hs1329 Neighboring gene microRNA 4288 Neighboring gene RNA, 5S ribosomal pseudogene 259 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:28415895-28416077 Neighboring gene NANOG hESC enhancer GRCh37_chr8:28419252-28419778 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:28479657-28480093 Neighboring gene exostosin like glycosyltransferase 3 Neighboring gene Sharpr-MPRA regulatory region 11135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19063 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19064 Neighboring gene EXTL3 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28583611-28584110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:28609290-28610234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:28610235-28611177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19065 Neighboring gene uncharacterized LOC124902104 Neighboring gene integrator complex subunit 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity  
    enables PDZ domain binding PubMed 
    enables Wnt receptor activity  
    enables Wnt receptor activity PubMed 
    enables Wnt receptor activity PubMed 
    enables Wnt-protein binding  
    enables Wnt-protein binding PubMed 
    enables Wnt-protein binding PubMed 
    enables protein binding  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in Wnt signaling pathway, planar cell polarity pathway PubMed 
    involved_in canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway PubMed 
    involved_in cell proliferation in midbrain  
    involved_in commissural neuron axon guidance  
    involved_in dopaminergic neuron axon guidance  
    involved_in establishment of planar polarity  
    involved_in hair follicle development  
    involved_in inner ear morphogenesis  
    involved_in midbrain morphogenesis PubMed 
    involved_in motor neuron migration  
    involved_in negative regulation of execution phase of apoptosis  
    involved_in negative regulation of mitotic cell cycle, embryonic  
    involved_in neural tube closure  
    involved_in neuron differentiation  
    involved_in non-canonical Wnt signaling pathway  
    involved_in positive regulation of neuroblast proliferation  
    involved_in post-anal tail morphogenesis  
    involved_in response to electrical stimulus  
    involved_in response to xenobiotic stimulus  
    involved_in serotonergic neuron axon guidance  
    involved_in sympathetic ganglion development  
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    located_in axon  
    located_in cell surface  
    located_in cytoplasm PubMed 
    located_in dendrite  
    located_in filopodium tip  
    located_in glutamatergic synapse  
    located_in lateral plasma membrane  
    located_in neuronal cell body  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in presynaptic active zone membrane  

    General protein information

    Preferred Names
    frizzled-3
    Names
    frizzled 3, seven transmembrane spanning receptor
    frizzled family receptor 3
    frizzled homolog 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029723.1 RefSeqGene

      Range
      5008..85054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_859

    mRNA and Protein(s)

    1. NM_001412905.1 → NP_001399834.1  frizzled-3 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC011132
    2. NM_001412906.1 → NP_001399835.1  frizzled-3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC011132
    3. NM_001412908.1 → NP_001399837.1  frizzled-3 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011132
    4. NM_001412909.1 → NP_001399838.1  frizzled-3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC011132
    5. NM_001412910.1 → NP_001399839.1  frizzled-3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC011132
    6. NM_001412911.1 → NP_001399840.1  frizzled-3 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC011132
      UniProtKB/Swiss-Prot
      A8K615, Q9NPG1
    7. NM_001412912.1 → NP_001399841.1  frizzled-3 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC011132
    8. NM_001412913.1 → NP_001399842.1  frizzled-3 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC011132
    9. NM_001412917.1 → NP_001399846.1  frizzled-3 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC011132
    10. NM_001412919.1 → NP_001399848.1  frizzled-3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC011132
    11. NM_001412921.1 → NP_001399850.1  frizzled-3 isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AC011132
    12. NM_001412922.1 → NP_001399851.1  frizzled-3 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC011132
    13. NM_001412924.1 → NP_001399853.1  frizzled-3 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011132
    14. NM_001412925.1 → NP_001399854.1  frizzled-3 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011132
    15. NM_001412927.1 → NP_001399856.1  frizzled-3 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC011132
    16. NM_017412.4 → NP_059108.1  frizzled-3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_059108.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB039723, AC011132, BU676090, DA250029
      Consensus CDS
      CCDS6069.1
      UniProtKB/Swiss-Prot
      A8K615, Q9NPG1
      Related
      ENSP00000240093.3, ENST00000240093.8
      Conserved Domains (2) summary
      cd07449
      Location:24 → 150
      CRD_FZ3; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 3 (Fz3) receptor
      cd15033
      Location:192 → 512
      7tmF_FZD3; class F frizzled subfamily 3, member of 7-transmembrane G protein-coupled receptors
    17. NM_145866.2 → NP_665873.1  frizzled-3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_665873.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC011132, AK291480, BU676090
      Consensus CDS
      CCDS6069.1
      UniProtKB/Swiss-Prot
      A8K615, Q9NPG1
      Related
      ENSP00000437489.1, ENST00000537916.2
      Conserved Domains (2) summary
      cd07449
      Location:24 → 150
      CRD_FZ3; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 3 (Fz3) receptor
      cd15033
      Location:192 → 512
      7tmF_FZD3; class F frizzled subfamily 3, member of 7-transmembrane G protein-coupled receptors

    RNA

    1. NR_182065.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011132
    2. NR_182066.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011132
    3. NR_182067.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011132
    4. NR_182068.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011132
    5. NR_182069.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011132
    6. NR_182070.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011132
    7. NR_182071.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011132
    8. NR_197428.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011132

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      28494212..28574258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422238.1 → XP_047278194.1  frizzled-3 isoform X2

    2. XM_017013843.2 → XP_016869332.1  frizzled-3 isoform X4

    3. XM_047422239.1 → XP_047278195.1  frizzled-3 isoform X4

    4. XM_017013844.2 → XP_016869333.1  frizzled-3 isoform X5

    5. XM_017013842.2 → XP_016869331.1  frizzled-3 isoform X3

    6. XM_017013841.2 → XP_016869330.1  frizzled-3 isoform X1

      Conserved Domains (2) summary
      cd15033
      Location:125 → 445
      7tmF_FZD3; class F frizzled subfamily 3, member of 7-transmembrane G protein-coupled receptors
      cl02447
      Location:1 → 83
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      28772375..28852426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361241.1 → XP_054217216.1  frizzled-3 isoform X4

    2. XM_054361243.1 → XP_054217218.1  frizzled-3 isoform X4

    3. XM_054361242.1 → XP_054217217.1  frizzled-3 isoform X5

    4. XM_054361240.1 → XP_054217215.1  frizzled-3 isoform X3

    5. XM_054361239.1 → XP_054217214.1  frizzled-3 isoform X1

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