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    ASP1 aspartate aminotransferase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817648, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ASP1
    Official Full Name
    aspartate aminotransferase 1
    Primary source
    TAIR:AT2G30970
    Locus tag
    AT2G30970
    See related
    Araport:AT2G30970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    aspartate aminotransferase 1; ASPARTATE AMINOTRANSFERASE 1; F7F1.18; F7F1_18
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    Genomic context

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    See ASP1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (13178829..13182050)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene FtsH extracellular protease family Neighboring gene ncRNA Neighboring gene myosin-M heavy chain-like protein Neighboring gene ncRNA Neighboring gene SHAGGY-related protein kinase dZeta Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene arginine N-methyltransferase, putative (DUF688)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recombinant expression, purification, and characterization of three isoenzymes of aspartate aminotransferase from Arabidopsis thaliana. Wilkie SE, et al. Protein Expr Purif, 1998 Apr. PMID 9535706
    2. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124
    3. Analysis of the Arabidopsis mitochondrial proteome. Millar AH, et al. Plant Physiol, 2001 Dec. PMID 11743115, Free PMC Article
    4. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article
    5. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001124949.1
    NM_128651.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-aspartate:2-oxoglutarate aminotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-aspartate:2-oxoglutarate aminotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables copper ion binding HDA PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in aspartate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome HDA PubMed 

    General protein information

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    Preferred Names
    aspartate aminotransferase 1
    NP_001118421.1
    • aspartate aminotransferase 1 (ASP1); FUNCTIONS IN: L-aspartate:2-oxoglutarate aminotransferase activity, copper ion binding; LOCATED IN: mitochondrion; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aminotransferase, class I/classII (InterPro:IPR004839), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferases, class-I, pyridoxal-phosphate-binding site (InterPro:IPR004838), Aspartate/other aminotransferase (InterPro:IPR000796), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: aspartate aminotransferase 2 (TAIR:AT5G19550.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_180654.1
    • aspartate aminotransferase 1 (ASP1); FUNCTIONS IN: L-aspartate:2-oxoglutarate aminotransferase activity, copper ion binding; INVOLVED IN: response to cadmium ion; LOCATED IN: mitochondrion; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aminotransferase, class I/classII (InterPro:IPR004839), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferases, class-I, pyridoxal-phosphate-binding site (InterPro:IPR004838), Aspartate/other aminotransferase (InterPro:IPR000796), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: aspartate aminotransferase 2 (TAIR:AT5G19550.1); Has 5625 Blast hits to 5619 proteins in 1351 species: Archae - 10; Bacteria - 3742; Metazoa - 486; Fungi - 406; Plants - 379; Viruses - 0; Other Eukaryotes - 602 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      13178829..13182050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128651.5 → NP_180654.1  aspartate aminotransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180654.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46643
      UniProtKB/TrEMBL
      A0A178VP87, A0A5S9X2R5
      Conserved Domains (2) summary
      PLN02397
      Location:10 → 429
      PLN02397; aspartate transaminase
      pfam00155
      Location:57 → 423
      Aminotran_1_2; Aminotransferase class I and II

    2. NM_001124949.1 → NP_001118421.1  aspartate aminotransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118421.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46643
      UniProtKB/TrEMBL
      A0A178VP87, A0A5S9X2R5
      Conserved Domains (2) summary
      PLN02397
      Location:10 → 429
      PLN02397; aspartate transaminase
      pfam00155
      Location:57 → 423
      Aminotran_1_2; Aminotransferase class I and II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46643.1

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