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    NDA2 alternative NAD(P)H dehydrogenase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817549, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NDA2
    Official Full Name
    alternative NAD(P)H dehydrogenase 2
    Primary source
    TAIR:AT2G29990
    Locus tag
    AT2G29990
    See related
    Araport:AT2G29990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    alternative NAD(P)H dehydrogenase 2; F23F1.9; F23F1_9
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    Genomic context

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    See NDA2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (12793320..12796085, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Double Clp-N motif-containing P-loop nucleoside triphosphate hydrolases superfamily protein Neighboring gene fatty acid desaturase 3 Neighboring gene PSY3-like protein Neighboring gene PHF5-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial alternative NADH dehydrogenases NDA1 and NDA2 promote survival of reoxygenation stress in Arabidopsis by safeguarding photosynthesis and limiting ROS generation. Jethva J, et al. New Phytol, 2023 Apr. PMID 36464787
    2. Suppression of NDA-type alternative mitochondrial NAD(P)H dehydrogenases in arabidopsis thaliana modifies growth and metabolism, but not high light stimulation of mitochondrial electron transport. Wallström SV, et al. Plant Cell Physiol, 2014 May. PMID 24486764, Free PMC Article
    3. Type II NAD(P)H dehydrogenases are targeted to mitochondria and chloroplasts or peroxisomes in Arabidopsis thaliana. Carrie C, et al. FEBS Lett, 2008 Sep 3. PMID 18703057
    4. Characterization of mitochondrial alternative NAD(P)H dehydrogenases in Arabidopsis: intraorganelle location and expression. Elhafez D, et al. Plant Cell Physiol, 2006 Jan. PMID 16258072
    5. Arabidopsis genes encoding mitochondrial type II NAD(P)H dehydrogenases have different evolutionary origin and show distinct responses to light. Michalecka AM, et al. Plant Physiol, 2003 Oct. PMID 12972666, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitochondrial alternative NADH dehydrogenases NDA1 and NDA2 promote survival of reoxygenation stress in Arabidopsis by safeguarding photosynthesis and limiting ROS generation.
      Title: Mitochondrial alternative NADH dehydrogenases NDA1 and NDA2 promote survival of reoxygenation stress in Arabidopsis by safeguarding photosynthesis and limiting ROS generation.
    2. Data indicate that suppressing the type II NAD(P)H dehydrogenase genes NDA1 (BT005564.1) and NDA2. (NM_128553.2) substantially reduced levels of both proteins in leaf mitochondria.
      Title: Suppression of NDA-type alternative mitochondrial NAD(P)H dehydrogenases in arabidopsis thaliana modifies growth and metabolism, but not high light stimulation of mitochondrial electron transport.
    Submit: New GeneRIF Correction

    General gene information

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    NM_128553.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NADPH dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADH oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alternative NAD(P)H dehydrogenase 2
    NP_180560.1
    • alternative NAD(P)H dehydrogenase 2 (NDA2); FUNCTIONS IN: NADH dehydrogenase activity, oxidoreductase activity, FAD binding; INVOLVED IN: oxidation reduction; LOCATED IN: intrinsic to mitochondrial inner membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: alternative NAD(P)H dehydrogenase 1 (TAIR:AT1G07180.1); Has 11797 Blast hits to 11597 proteins in 2273 species: Archae - 301; Bacteria - 9312; Metazoa - 49; Fungi - 695; Plants - 411; Viruses - 0; Other Eukaryotes - 1029 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12793320..12796085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128553.3 → NP_180560.1  alternative NAD(P)H dehydrogenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180560.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80874
      UniProtKB/TrEMBL
      A0A5S9X2L2, A0A654EYI6
      Conserved Domains (1) summary
      PTZ00318
      Location:65 → 508
      PTZ00318; NADH dehydrogenase-like protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80874.1

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