WUS Homeodomain-like superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: WUS
Official Full Name: Homeodomain-like superfamily protein
Primary source: TAIR:AT2G17950
Locus tag: AT2G17950
See related: Araport:AT2G17950
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: PGA6; T27K22.18; T27K22_18; WUS1; WUSCHEL; WUSCHEL 1
Summary: Homeobox gene controlling the stem cell pool. Expressed in the stem cell organizing center of meristems. Required to keep the stem cells in an undifferentiated state. Regulation of WUS transcription is a central checkpoint in stem cell control. The size of the WUS expression domain controls the size of the stem cell population through WUS indirectly activating the expression of CLAVATA3 (CLV3) in the stem cells and CLV3 repressing WUS transcription through the CLV1 receptor kinase signaling pathway. Repression of WUS transcription through AGAMOUS (AG) activity controls stem cell activity in the determinate floral meristem. Binds to TAAT element core motif. WUS is also involved in cell differentiation during anther development.
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Genomic context

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See WUS in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 3

Sequence:: Chromosome: 2; NC_003071.7 (7808871..7810811, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Control of Arabidopsis shoot stem cell homeostasis by two antagonistic CLE peptide signalling pathways.
Title: Control of Arabidopsis shoot stem cell homeostasis by two antagonistic CLE peptide signalling pathways.
WUSCHEL: the versatile protein in the shoot apical meristem.
Title: WUSCHEL: the versatile protein in the shoot apical meristem.
WUSCHEL in the shoot apical meristem: old player, new tricks.
Title: WUSCHEL in the shoot apical meristem: old player, new tricks.
WUSCHEL triggers innate antiviral immunity in plant stem cells.
Title: WUSCHEL triggers innate antiviral immunity in plant stem cells.
Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL.
Title: Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL.
KNU integrates initial transcriptional repression with polycomb-mediated stable silencing of WUS.
Title: Integration of Transcriptional Repression and Polycomb-Mediated Silencing of WUSCHEL in Floral Meristems.
In apical stem cells, WUSCHEL transcription factor confers resistance to auxin mediated differentiation by rheostatically controlling the auxin signaling and response pathway. WUSCHEL acts via regulation of histone acetylation at target loci, including those with functions in the auxin pathway.
Title: WUSCHEL acts as an auxin response rheostat to maintain apical stem cells in Arabidopsis.
The S-acylated form of C4 interacts with CLAVATA 1 (CLV1), an important receptor kinase in meristem maintenance, and consequentially affects the expression of WUSCHEL, a major target of CLV1.
Title: S-acylation of a geminivirus C4 protein is essential for regulating the CLAVATA pathway in symptom determination.
Study find that WUSCHEL, a key gene required for apical meristem maintenance, is a cytokinin-dependent type-B ARABIDOPSIS RESPONSE REGULATORS target gene, demonstrating the importance of the cytokinin transcription factor network in shoot development.
Title: A B-ARR-mediated cytokinin transcriptional network directs hormone cross-regulation and shoot development.
Cytokinin signaling in the rib meristem acts through the transcriptional regulatory domains, the acidic domain and the WUSCHEL-box, to stabilize the WUS protein.
Title: Cytokinin stabilizes WUSCHEL by acting on the protein domains required for nuclear enrichment and transcription.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_127349.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anther development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axillary shoot meristem initiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maintenance of shoot apical meristem identity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
NOT involved_in stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stomium development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Homeodomain-like superfamily protein

NP_565429.1

WUSCHEL (WUS); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057); BEST Arabidopsis thaliana protein match is: WUSCHEL related homeobox 1 (TAIR:AT3G18010.1); Has 617 Blast hits to 617 proteins in 63 species: Archae - 0; Bacteria - 0; Metazoa - 29; Fungi - 2; Plants - 575; Viruses - 0; Other Eukaryotes - 11 (source: NCBI BLink).