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    MLO7 Seven transmembrane MLO family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816249, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MLO7
    Official Full Name
    Seven transmembrane MLO family protein
    Primary source
    TAIR:AT2G17430
    Locus tag
    AT2G17430
    See related
    Araport:AT2G17430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMLO7; F5J6.19; F5J6_19; MILDEW RESISTANCE LOCUS O 7; NORTIA; NTA
    Summary
    A member of a large family of seven-transmembrane domain proteins specific to plants, homologs of the barley mildew resistance locus o (MLO) protein. Controls pollen tube reception in synergids. The Arabidopsis genome contains 15 genes encoding MLO proteins, with localization in plasma membrane. Phylogenetic analysis revealed four clades of closely-related AtMLO genes. ATMLO7 belongs to the clade III, with AtMLO5, AtMLO8, AtMLO9, and AtMLO10. The gene is expressed in vegetative organs (RT-PCR experiments)and in pollen grains, as shown by GUS activity patterns. The expression of several phylogenetically closely-related AtMLO genes showed similar or overlapping tissue specificity and analogous responsiveness to external stimuli, suggesting functional redundancy, co-function, or antagonistic function(s).
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    Genomic context

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    See MLO7 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    14
    Sequence:
    Chromosome: 2; NC_003071.7 (7568018..7570912)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ARID/BRIGHT DNA-binding domain-containing protein Neighboring gene NADPH-dependent thioredoxin reductase A Neighboring gene plant intracellular ras group-related LRR 5 Neighboring gene uncharacterized protein Neighboring gene RING-H2 finger A3A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MILDEW RESISTANCE LOCUS O Function in Pollen Tube Reception Is Linked to Its Oligomerization and Subcellular Distribution. Jones DS, et al. Plant Physiol, 2017 Sep. PMID 28724621, Free PMC Article
    2. Conserved molecular components for pollen tube reception and fungal invasion. Kessler SA, et al. Science, 2010 Nov 12. PMID 21071669
    3. A receptor-channel trio conducts Ca(2+) signalling for pollen tube reception. Gao Q, et al. Nature, 2022 Jul. PMID 35794475, Free PMC Article
    4. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A receptor-channel trio conducts Ca(2+) signalling for pollen tube reception.
      Title: A receptor-channel trio conducts Ca(2+) signalling for pollen tube reception.
    2. critical role in pollen tube reception dependent on localization within synergids into a Golgi-associated compartment before pollen tube arrival, indicating that pollen tube-triggered regulation of the synergid secretory system is important for synergid function during pollination
      Title: MILDEW RESISTANCE LOCUS O Function in Pollen Tube Reception Is Linked to Its Oligomerization and Subcellular Distribution.
    3. study shows pollen tube (PT) reception and powdery mildew (PM) infection share molecular components; NTA, discovered in context of PM resistance, and FERONIA control PT reception; fer mutants also display PM resistance revealing a new function for FER
      Title: Conserved molecular components for pollen tube reception and fungal invasion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_127298.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within pollen tube reception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Seven transmembrane MLO family protein
    NP_179335.3
    • MILDEW RESISTANCE LOCUS O 7 (MLO7); FUNCTIONS IN: calmodulin binding; INVOLVED IN: cell death, defense response; LOCATED IN: integral to membrane, plasma membrane; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: seedling growth, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Mlo-related protein (InterPro:IPR004326); BEST Arabidopsis thaliana protein match is: Seven transmembrane MLO family protein (TAIR:AT5G65970.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7568018..7570912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127298.5 → NP_179335.3  Seven transmembrane MLO family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179335.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22752, Q94KB6
      UniProtKB/TrEMBL
      A0A178VXK5, A0A5S9WYP9, A0A654EUX4
      Conserved Domains (1) summary
      pfam03094
      Location:35 → 476
      Mlo; Mlo family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22752.3

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