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    ORC4 origin recognition complex subunit 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814641, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ORC4
    Official Full Name
    origin recognition complex subunit 4
    Primary source
    TAIR:AT2G01120
    Locus tag
    AT2G01120
    See related
    Araport:AT2G01120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATORC4; F23H14.9; F23H14_9; origin recognition complex subunit 4; ORIGIN RECOGNITION COMPLEX SUBUNIT 4
    Summary
    Origin Recognition Complex subunit 4. Involved in the initiation of DNA replication. Regulated transcriptionally during cell cycle, peaking at G1/S-phase. Target of E2F/DF family of transcription factors. Interacts with all ORC subunits except ORC1b.
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    Genomic context

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    See ORC4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Sequence:
    Chromosome: 2; NC_003071.7 (85401..88399)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Ubiquinol-cytochrome C reductase hinge protein Neighboring gene FAM133-like protein Neighboring gene Sec-independent periplasmic protein translocase Neighboring gene ncRNA Neighboring gene DEA(D/H)-box RNA helicase family protein Neighboring gene Aldolase superfamily protein Neighboring gene RING-H2 finger protein 2B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The genes encoding Arabidopsis ORC subunits are E2F targets and the two ORC1 genes are differently expressed in proliferating and endoreplicating cells. Diaz-Trivino S, et al. Nucleic Acids Res, 2005. PMID 16179646, Free PMC Article
    2. ABAP1 is a novel plant Armadillo BTB protein involved in DNA replication and transcription. Masuda HP, et al. EMBO J, 2008 Oct 22. PMID 18818695, Free PMC Article
    3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001202564.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of origin recognition complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    origin recognition complex subunit 4
    NP_001189493.1
    • origin recognition complex subunit 4 (ORC4); CONTAINS InterPro DOMAIN/s: ATPase, AAA-type, core (InterPro:IPR003959), Origin recognition complex, subunit 4 (InterPro:IPR016527).
    NP_178222.4
    • origin recognition complex subunit 4 (ORC4); CONTAINS InterPro DOMAIN/s: ATPase, AAA-type, core (InterPro:IPR003959), Origin recognition complex, subunit 4 (InterPro:IPR016527); Has 675 Blast hits to 668 proteins in 199 species: Archae - 9; Bacteria - 0; Metazoa - 335; Fungi - 166; Plants - 90; Viruses - 0; Other Eukaryotes - 75 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      85401..88399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126174.5 → NP_178222.4  origin recognition complex subunit 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178222.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IM83, Q6E7G9, Q6EWX1, Q70BT4, Q9SJV4
      UniProtKB/TrEMBL
      A0A5S9WW79
      Conserved Domains (3) summary
      cd00009
      Location:53 → 205
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      COG1474
      Location:33 → 257
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:217 → 392
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    2. NM_001202564.1 → NP_001189493.1  origin recognition complex subunit 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189493.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IM83, Q6E7G9, Q6EWX1, Q70BT4, Q9SJV4
      UniProtKB/TrEMBL
      A0A5S9WW79, F4IM82
      Conserved Domains (3) summary
      cd00009
      Location:53 → 205
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      COG1474
      Location:33 → 257
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:217 → 398
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
    Nucleotide Protein
    Heading Accession and Version

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