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    D-isomer specific 2-hydroxyacid dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844326, updated on 18-Sep-2024

    Summary

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    Official Full Name
    D-isomer specific 2-hydroxyacid dehydrogenase family protein
    Primary source
    TAIR:AT1G79870
    Locus tag
    AT1G79870
    See related
    Araport:AT1G79870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F19K16.17; F19K16_17
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (30044746..30046148)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene HD-ZIP IV family of homeobox-leucine zipper protein with lipid-binding START domain-containing protein Neighboring gene ncRNA Neighboring gene RHO guanyl-nucleotide exchange factor 12 Neighboring gene ribosomal protein S17 Neighboring gene RNA recognition motif (RRM)-containing protein Neighboring gene RAD3-like DNA-binding helicase protein Neighboring gene Mitochondrial substrate carrier family protein Neighboring gene Regulator of Vps4 activity in the MVB pathway protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cytosolic pathway for the conversion of hydroxypyruvate to glycerate during photorespiration in Arabidopsis. Timm S, et al. Plant Cell, 2008 Oct. PMID 18952776, Free PMC Article
    2. Characterization of Arabidopsis thaliana Hydroxyphenylpyruvate Reductases in the Tyrosine Conversion Pathway. Xu JJ, et al. Front Plant Sci, 2018. PMID 30233632, Free PMC Article
    3. Identification of multiple salicylic acid-binding proteins using two high throughput screens. Manohar M, et al. Front Plant Sci, 2014. PMID 25628632, Free PMC Article
    4. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AT1G79870 encodes HPR2, a hydroxypyruvate reductase that functions in the cytosol, providing a cytosolic bypass to the photorespiratory cycle.
      Title: A cytosolic pathway for the conversion of hydroxypyruvate to glycerate during photorespiration in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001198515.1
    NM_106636.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyoxylate reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydroxyphenylpyruvate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydroxypyruvate reductase [NAD(P)H] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables salicylic acid binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in oxidative photosynthetic carbon pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    colocalizes_with cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    D-isomer specific 2-hydroxyacid dehydrogenase family protein
    NP_001185444.1
    • D-isomer specific 2-hydroxyacid dehydrogenase family protein; FUNCTIONS IN: in 6 functions; INVOLVED IN: metabolic process; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (InterPro:IPR006139), D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding (InterPro:IPR006140), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: D-isomer specific 2-hydroxyacid dehydrogenase family protein (TAIR:AT1G12550.1).
    NP_178105.1
    • D-isomer specific 2-hydroxyacid dehydrogenase family protein; FUNCTIONS IN: in 6 functions; INVOLVED IN: metabolic process; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (InterPro:IPR006139), D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding (InterPro:IPR006140), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: D-isomer specific 2-hydroxyacid dehydrogenase family protein (TAIR:AT1G12550.1); Has 29704 Blast hits to 29696 proteins in 2729 species: Archae - 468; Bacteria - 18164; Metazoa - 733; Fungi - 1180; Plants - 594; Viruses - 5; Other Eukaryotes - 8560 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30044746..30046148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106636.3 → NP_178105.1  D-isomer specific 2-hydroxyacid dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178105.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HQC5, Q9CA90
      UniProtKB/TrEMBL
      A0A178W4H7, A0A5S9WVW4
      Conserved Domains (1) summary
      cd12156
      Location:4 → 304
      HPPR; Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase

    2. NM_001198515.1 → NP_001185444.1  D-isomer specific 2-hydroxyacid dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185444.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9CA90
      Conserved Domains (2) summary
      COG1052
      Location:4 → 293
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd12156
      Location:4 → 285
      HPPR; Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CA90.1

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