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    ISU2 ISCU-like 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821316, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ISU2
    Official Full Name
    ISCU-like 2
    Primary source
    TAIR:AT3G01020
    Locus tag
    AT3G01020
    See related
    Araport:AT3G01020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATISU2; ISCU-like 2; ISCU-LIKE 2; T4P13.30; T4P13_30
    Summary
    Encodes a mitochondrial protein similar to E.coli IscU. In bacteria, IscU is a scaffold protein accepting sulfur and iron to build a transient Fe-S cluster,which is subsequently transferred to a target apoprotein.
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    Genomic context

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    See ISU2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (5104..6149)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene TPX2 (targeting protein for Xklp2) protein family Neighboring gene UDP-glucose/GDP-mannose dehydrogenase family protein Neighboring gene C2H2 and C2HC zinc fingers superfamily protein Neighboring gene galacturonosyltransferase 13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial localization of Arabidopsis thaliana Isu Fe-S scaffold proteins. Léon S, et al. FEBS Lett, 2005 Mar 28. PMID 15792798
    2. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_110967.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within iron-sulfur cluster assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ISCU-like 2
    NP_186751.1
    • ISCU-like 2 (ISU2); CONTAINS InterPro DOMAIN/s: NIF system FeS cluster assembly, NifU, N-terminal (InterPro:IPR002871), ISC system FeS cluster assembly, IscU scaffold (InterPro:IPR011339); BEST Arabidopsis thaliana protein match is: SufE/NifU family protein (TAIR:AT4G22220.1); Has 5480 Blast hits to 5480 proteins in 1991 species: Archae - 108; Bacteria - 3649; Metazoa - 148; Fungi - 153; Plants - 89; Viruses - 0; Other Eukaryotes - 1333 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5104..6149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_110967.3 → NP_186751.1  ISCU-like 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_186751.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2WEB4, Q9MAB6
      UniProtKB/TrEMBL
      A0A178VN22, A0A5S9X800
      Conserved Domains (1) summary
      cl00528
      Location:27 → 151
      IscU_like; Iron-sulfur cluster scaffold-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MAB6.1

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