ADA2A ADA2 2A [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ADA2A
Official Full Name: ADA2 2A
Primary source: TAIR:AT3G07740
Locus tag: AT3G07740
See related: Araport:AT3G07740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATADA2A; HAC10; homolog of yeast ADA2 2A; HXA02; HXA2
Summary: encodes a transcriptional adaptor ADA2a that interacts with histone acetyltransferase GCN5 homolog and CBF1
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Genomic context

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See ADA2A in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 13

Sequence:: Chromosome: 3; NC_003074.8 (2469783..2473095, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that ADA2a and ADA2b each work independently with GCN5 to affect genome function in Arabidopsis.
Title: Two Arabidopsis orthologs of the transcriptional coactivator ADA2 have distinct biological functions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001084653.2

Supported by ESTs:

NM_001202911.1

Supported by ESTs:

NM_111653.2

Supported by ESTs:

NM_202522.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cold	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: ADA2 2A

NP_001078122.2

homolog of yeast ADA2 2A (ADA2A); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding; INVOLVED IN: response to cold; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: SANT, eukarya (InterPro:IPR017884), SANT, DNA-binding (InterPro:IPR001005), Transcriptional adaptor 2 (InterPro:IPR016827), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), SWIRM (InterPro:IPR007526), Zinc finger, ZZ-type (InterPro:IPR000433); BEST Arabidopsis thaliana protein match is: homolog of yeast ADA2 2B (TAIR:AT4G16420.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_001189840.1

homolog of yeast ADA2 2A (ADA2A); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding; INVOLVED IN: response to cold; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: SANT, eukarya (InterPro:IPR017884), SANT, DNA-binding (InterPro:IPR001005), Transcriptional adaptor 2 (InterPro:IPR016827), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), SWIRM (InterPro:IPR007526), Zinc finger, ZZ-type (InterPro:IPR000433); BEST Arabidopsis thaliana protein match is: homolog of yeast ADA2 2B (TAIR:AT4G16420.2).

NP_566317.1

homolog of yeast ADA2 2A (ADA2A); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding; INVOLVED IN: response to cold; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Transcriptional adaptor 2 (InterPro:IPR016827), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), SWIRM (InterPro:IPR007526), SANT, eukarya (InterPro:IPR017884), Zinc finger, ZZ-type (InterPro:IPR000433); BEST Arabidopsis thaliana protein match is: homolog of yeast ADA2 2B (TAIR:AT4G16420.2); Has 1807 Blast hits to 1600 proteins in 233 species: Archae - 4; Bacteria - 36; Metazoa - 932; Fungi - 285; Plants - 203; Viruses - 0; Other Eukaryotes - 347 (source: NCBI BLink).

NP_974251.1

homolog of yeast ADA2 2A (ADA2A); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to cold; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Transcriptional adaptor 2 (InterPro:IPR016827), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), SWIRM (InterPro:IPR007526), SANT, eukarya (InterPro:IPR017884); BEST Arabidopsis thaliana protein match is: homolog of yeast ADA2 2B (TAIR:AT4G16420.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

2469783..2473095 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_111653.2 → NP_566317.1 ADA2 2A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566317.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SFD5, Q9SSE2

UniProtKB/TrEMBL

A0A178V617, A0A5S9XA26, A0A654F6B3

Conserved Domains (2) summary

COG5114
Location:51 → 548

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

PRK02597
Location:233 → 313

rpoC2; DNA-directed RNA polymerase subunit beta'; Provisional
NM_202522.1 → NP_974251.1 ADA2 2A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974251.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V617

Conserved Domains (3) summary

COG5114
Location:2 → 477

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

cd00167
Location:40 → 80

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cl00295
Location:1 → 28

ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
NM_001084653.2 → NP_001078122.2 ADA2 2A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078122.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V617, A8MRD5

Conserved Domains (3) summary

COG5114
Location:30 → 527

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

cd00167
Location:90 → 130

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cd02335
Location:30 → 78

ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
NM_001202911.1 → NP_001189840.1 ADA2 2A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189840.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V617, F4JFM6

Conserved Domains (3) summary

COG5114
Location:51 → 555

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

cd00167
Location:118 → 158

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cd02335
Location:51 → 99

ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.