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    MKK5 MAP kinase kinase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821676, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MKK5
    Official Full Name
    MAP kinase kinase 5
    Primary source
    TAIR:AT3G21220
    Locus tag
    AT3G21220
    See related
    Araport:AT3G21220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5; ATMAP2K_ALPHA; ATMEK5; ATMKK5; MAP kinase kinase 5; MAP KINASE KINASE 5; MAP2K_A; MEK5
    Summary
    Encodes a mitogen-activated kinase kinase, dual specific protein kinase that is expressed in vegetative tissues and floral buds. Involved in innate immunity. This protein activates MPK3/MPK6 and early-defense genes redundantly with MKK4.In plants with both MKK5 and MKK6 levels reduced by RNAi plants, floral organs do not abscise suggestion a role for both proteins in mediating floral organ abscission.
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    Genomic context

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    See MKK5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (7445604..7448498)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene proton gradient regulation 7 Neighboring gene zinc ion binding protein Neighboring gene ncRNA Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene 4-coumarate:CoA ligase 5 Neighboring gene 4-coumarate:CoA ligase 2 Neighboring gene multidrug resistance-associated protein 6 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Raf-like MAPKKK INTEGRIN-LINKED KINASE 5 regulates purinergic receptor-mediated innate immunity in Arabidopsis. Kim D, et al. Plant Cell, 2023 Apr 20. PMID 36762404, Free PMC Article
    2. Ethylene signaling is required for the acceleration of cell death induced by the activation of AtMEK5 in Arabidopsis. Liu H, et al. Cell Res, 2008 Mar. PMID 18268539
    3. Regulation of floral organ abscission in Arabidopsis thaliana. Cho SK, et al. Proc Natl Acad Sci U S A, 2008 Oct 7. PMID 18809915, Free PMC Article
    4. Abscisic acid signaling is involved in regulating the mitogen-activated protein kinase cascade module, AIK1-MKK5-MPK6. Li K, et al. Plant Signal Behav, 2017 May 4. PMID 28494202, Free PMC Article
    5. Arabidopsis E3 ligase KEG associates with and ubiquitinates MKK4 and MKK5 to regulate plant immunity. Gao C, et al. J Integr Plant Biol, 2021 Feb. PMID 32877006

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Raf-like MAPKKK INTEGRIN-LINKED KINASE 5 regulates purinergic receptor-mediated innate immunity in Arabidopsis.
      Title: The Raf-like MAPKKK INTEGRIN-LINKED KINASE 5 regulates purinergic receptor-mediated innate immunity in Arabidopsis.
    2. Arabidopsis E3 ligase KEG associates with and ubiquitinates MKK4 and MKK5 to regulate plant immunity.
      Title: Arabidopsis E3 ligase KEG associates with and ubiquitinates MKK4 and MKK5 to regulate plant immunity.
    3. The Arabidopsis MKK4/MKK5-MPK6 cascade is an important player in the maternal control of embryogenesis.
      Title: Maternal control of embryogenesis by MPK6 and its upstream MKK4/MKK5 in Arabidopsis.
    4. results indicated that AIK1-MKK5-MPK6 functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK cascade.
      Title: Abscisic acid signaling is involved in regulating the mitogen-activated protein kinase cascade module, AIK1-MKK5-MPK6.
    5. AIK1-MKK5-MPK6 cascade functions in the abscisic acid regulation of primary root growth and stomatal response.
      Title: AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade.
    6. MKK4, MKK5, MKK7, and MKK9, are responsible for the activation of MPK3 and MPK6 by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK signaling through MKK4/5/7/9-MPK3/6 cascades.
      Title: Mitogen-activated protein kinase pathways are required for melatonin-mediated defense responses in plants.
    7. Overexpression of MKK5 in wild-type plants enhanced their tolerance to salt treatments. Another kinase, MPK6, was also involved in the MKK5-mediated iron superoxide dismutase (FSD) signalling pathway in salt stress.
      Title: Mitogen-activated protein kinase kinase 5 (MKK5)-mediated signalling cascade regulates expression of iron superoxide dismutase gene in Arabidopsis under salinity stress.
    8. our data indicate that EDR1 physically associates with MKK4/MKK5 and negatively regulates the MAPK cascade to fine-tune plant innate immunity.
      Title: EDR1 physically interacts with MKK4/MKK5 and negatively regulates a MAP kinase cascade to modulate plant innate immunity.
    9. Data indicate that in the MKK5-RNAi (RNA interference) lines, the induction of CSD1 and CSD2 as well as the activation of MKK5 activity were completely arrested.
      Title: MKK5 regulates high light-induced gene expression of Cu/Zn superoxide dismutase 1 and 2 in Arabidopsis.
    10. Results suggest that the YDA-MKK4/MKK5-MPK3/MPK6 cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.
      Title: A MAPK cascade downstream of ERECTA receptor-like protein kinase regulates Arabidopsis inflorescence architecture by promoting localized cell proliferation.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001338511.1
    NM_113017.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to other organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within floral organ abscission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inflorescence development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ethylene biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of root meristem growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal complex patterning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase kinase 5
    NP_001319606.1
    • MAP kinase kinase 5 (MKK5); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: mitogen-activated protein kinase kinase 4 (TAIR:AT1G51660.1); Has 130143 Blast hits to 128581 proteins in 4761 species: Archae - 120; Bacteria - 15121; Metazoa - 48301; Fungi - 12721; Plants - 32333; Viruses - 542; Other Eukaryotes - 21005 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7445604..7448498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338511.1 → NP_001319606.1  MAP kinase kinase 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80398, Q8RXG3, Q96517
      UniProtKB/TrEMBL
      A0A178VIK5, A0A5S9XE64
      Conserved Domains (1) summary
      PLN00034
      Location:1 → 342
      PLN00034; mitogen-activated protein kinase kinase; Provisional

    2. NM_113017.4 → NP_188759.1  MAP kinase kinase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188759.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80398, Q8RXG3, Q96517
      UniProtKB/TrEMBL
      A0A178VIK5, A0A5S9XE64
      Conserved Domains (1) summary
      PLN00034
      Location:1 → 342
      PLN00034; mitogen-activated protein kinase kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RXG3.2

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