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    MDAR4 monodehydroascorbate reductase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822402, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MDAR4
    Official Full Name
    monodehydroascorbate reductase 4
    Primary source
    TAIR:AT3G27820
    Locus tag
    AT3G27820
    See related
    Araport:AT3G27820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMDAR4; monodehydroascorbate reductase 4; MONODEHYDROASCORBATE REDUCTASE 4
    Summary
    Encodes a peroxisome membrane-bound monodehydroascorbate reductase, involved in the ascorbate-glutathione cycle which removes toxic H2O2
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    Genomic context

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    See MDAR4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (10315010..10318154)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene myb domain protein 21 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene tRNA-Pro Neighboring gene ribosomal protein L12-A Neighboring gene Gamma-thionin family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MONODEHYROASCORBATE REDUCTASE4 is required for seed storage oil hydrolysis and postgerminative growth in Arabidopsis. Eastmond PJ. Plant Cell, 2007 Apr. PMID 17449810, Free PMC Article
    2. Arabidopsis peroxisomes possess functionally redundant membrane and matrix isoforms of monodehydroascorbate reductase. Lisenbee CS, et al. Plant J, 2005 Sep. PMID 16146528
    3. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MDAR4 component of the ascorbate-dependent electron transfer system is necessary to detoxify hydrogen peroxide which escapes from the peroxisome.
      Title: MONODEHYROASCORBATE REDUCTASE4 is required for seed storage oil hydrolysis and postgerminative growth in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_113698.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monodehydroascorbate reductase (NADH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monodehydroascorbate reductase (NADH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within hydrogen peroxide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hydrogen peroxide catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast envelope HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    monodehydroascorbate reductase 4
    NP_189420.1
    • monodehydroascorbate reductase 4 (MDAR4); FUNCTIONS IN: monodehydroascorbate reductase (NADH) activity; INVOLVED IN: hydrogen peroxide catabolic process; LOCATED IN: peroxisomal membrane, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: monodehydroascorbate reductase 1 (TAIR:AT3G52880.1); Has 27219 Blast hits to 27159 proteins in 2894 species: Archae - 579; Bacteria - 21951; Metazoa - 737; Fungi - 533; Plants - 600; Viruses - 0; Other Eukaryotes - 2819 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      10315010..10318154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113698.4 → NP_189420.1  monodehydroascorbate reductase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LK94
      UniProtKB/TrEMBL
      A0A178VES2, A0A5S9XHX6
      Conserved Domains (1) summary
      pfam07992
      Location:29 → 321
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LK94.1

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