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    DEG1 DegP protease 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822416, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DEG1
    Official Full Name
    DegP protease 1
    Primary source
    TAIR:AT3G27925
    Locus tag
    AT3G27925
    See related
    Araport:AT3G27925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Deg1; DegP protease 1; DEGP1; degradation of periplasmic proteins 1
    Summary
    Encodes a DegP protease; nuclear gene encoding chloroplast-targeted protease that can degrade two lumenal proteins, plastocyanin and OE33, suggesting a role as a general-purpose protease in the thylakoid lumen. Involved in the degradation of D1 protein of PS II, hence participating in the repair of PS II damages caused by photoinhibition.
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    Genomic context

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    See DEG1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (10365652..10369013, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene myb domain protein 0 Neighboring gene ncRNA Neighboring gene beta-galactosidase Neighboring gene LOB domain-containing protein 26

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of DegP, a serine protease associated with the luminal side of the thylakoid membrane. Itzhaki H, et al. J Biol Chem, 1998 Mar 20. PMID 9507020
    2. Expression and characterization of the thylakoid lumen protease DegP1 from Arabidopsis. Chassin Y, et al. Plant Physiol, 2002 Oct. PMID 12376650, Free PMC Article
    3. The thylakoid lumen protease Deg1 is involved in the repair of photosystem II from photoinhibition in Arabidopsis. Kapri-Pardes E, et al. Plant Cell, 2007 Mar. PMID 17351117, Free PMC Article
    4. The thylakoid protease Deg1 is involved in photosystem-II assembly in Arabidopsis thaliana. Sun X, et al. Plant J, 2010 Apr. PMID 20088900
    5. Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure. Kley J, et al. Nat Struct Mol Biol, 2011 Jun. PMID 21532594

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study shows that the flexible regions of protein D1 that protrude into the lumen can penetrate through the three side-openings of Deg1 and reach its internal proteolytic sites. This mode of action, facilitating cooperation between proteases on both sides of the thylakoid membranes, should be applicable to the degradation of other integral thylakoid membrane proteins as well.
      Title: Lumenal exposed regions of the D1 protein of PSII are long enough to be degraded by the chloroplast Deg1 protease.
    2. This work suggests that differences in protein abundance and proteolytic activity underlie the differential importance of Deg1 and Deg5-Deg8 protease complexes observed in vivo.
      Title: Differential Roles of the Thylakoid Lumenal Deg Protease Homologs in Chloroplast Proteostasis.
    3. Photoinhibitory treatment of Arabidopsis thaliana leaves activates Deg1-mediated proteolysis of the PSII core and antenna subunits.
      Title: High light stimulates Deg1-dependent cleavage of the minor LHCII antenna proteins CP26 and CP29 and the PsbS protein in Arabidopsis thaliana.
    4. Structural and biochemical analyses reveal that the inactive Deg1 monomer is transformed into the proteolytically active hexamer at acidic pH.
      Title: Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure.
    5. Deg1 directly interacts with PSII reaction center D2 protein, and functions in the assembly of PSII.
      Title: The thylakoid protease Deg1 is involved in photosystem-II assembly in Arabidopsis thaliana.
    6. These results suggest that Deg1 cooperates with the stroma-exposed proteases FtsH and Deg2 in degrading D1 protein during repair from photoinhibition by cleaving lumen-exposed regions of the protein.[Deg1]
      Title: The thylakoid lumen protease Deg1 is involved in the repair of photosystem II from photoinhibition in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_113709.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within photosystem II repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast thylakoid HDA PubMed 
    located_in chloroplast thylakoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast thylakoid lumen HDA PubMed 
    located_in chloroplast thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in thylakoid HDA PubMed 
    located_in thylakoid lumen HDA PubMed 

    General protein information

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    Preferred Names
    DegP protease 1
    NP_189431.2
    • DegP protease 1 (DEGP1); FUNCTIONS IN: serine-type peptidase activity, serine-type endopeptidase activity; INVOLVED IN: photosystem II repair, proteolysis, protein catabolic process; LOCATED IN: in 7 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Serine/cysteine peptidase, trypsin-like (InterPro:IPR009003), Peptidase S1C, HrtA/DegP2/Q/S (InterPro:IPR001940), Peptidase S1/S6, chymotrypsin/Hap (InterPro:IPR001254), PDZ/DHR/GLGF (InterPro:IPR001478); BEST Arabidopsis thaliana protein match is: Trypsin family protein with PDZ domain (TAIR:AT5G39830.1); Has 16838 Blast hits to 16778 proteins in 2643 species: Archae - 108; Bacteria - 11023; Metazoa - 354; Fungi - 149; Plants - 421; Viruses - 7; Other Eukaryotes - 4776 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      10365652..10369013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338921.1 → NP_001325789.1  DegP protease 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22609, Q94BX6, Q9LK85
      UniProtKB/TrEMBL
      A0A178V823, A0A5S9XGG0, A0A654FDA0
      Conserved Domains (1) summary
      TIGR02037
      Location:122 → 438
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

    2. NM_113709.5 → NP_189431.2  DegP protease 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189431.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22609, Q94BX6, Q9LK85
      UniProtKB/TrEMBL
      A0A178V823, A0A5S9XGG0, A0A654FDA0
      Conserved Domains (1) summary
      TIGR02037
      Location:122 → 438
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22609.2

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