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    BUBR1 BUB1-related (BUB1: budding uninhibited by benzymidazol 1) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817921, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BUBR1
    Official Full Name
    BUB1-related (BUB1: budding uninhibited by benzymidazol 1)
    Primary source
    TAIR:AT2G33560
    Locus tag
    AT2G33560
    See related
    Araport:AT2G33560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BUB1-related (BUB1: budding uninhibited by benzymidazol 1); F4P9.33; F4P9_33
    Summary
    Encodes BUBR1. May have the spindle assembly checkpoint protein functions conserved from yeast to humans.
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    Genomic context

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    See BUBR1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Sequence:
    Chromosome: 2; NC_003071.7 (14213601..14216054, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene C-terminal domain phosphatase-like 3 Neighboring gene Homeodomain-like superfamily protein Neighboring gene glycosyltransferase family protein (DUF23) Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spindle assembly checkpoint protein dynamics reveal conserved and unsuspected roles in plant cell division. Caillaud MC, et al. PLoS One, 2009 Aug 27. PMID 19710914, Free PMC Article
    2. Conserved CDC20 cell cycle functions are carried out by two of the five isoforms in Arabidopsis thaliana. Kevei Z, et al. PLoS One, 2011. PMID 21687678, Free PMC Article
    3. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001202739.2
    NM_128916.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromocenter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BUB1-related (BUB1: budding uninhibited by benzymidazol 1)
    NP_001189668.1
    • BUB1-related (BUB1: budding uninhibited by benzymidazol 1) (BUBR1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: mitotic cell cycle spindle assembly checkpoint; LOCATED IN: chromocenter, kinetochore; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Mitotic checkpoint serine/threonine protein kinase, Bub1 (InterPro:IPR015661), Mad3/BUB1 homology region 1 (InterPro:IPR013212); BEST Arabidopsis thaliana protein match is: Mad3/BUB1 homology region 1 (TAIR:AT5G05510.1).
    NP_565767.1
    • BUB1-related (BUB1: budding uninhibited by benzymidazol 1) (BUBR1); CONTAINS InterPro DOMAIN/s: Mitotic checkpoint serine/threonine protein kinase, Bub1 (InterPro:IPR015661), Mad3/BUB1 homology region 1 (InterPro:IPR013212); BEST Arabidopsis thaliana protein match is: Mad3/BUB1 homology region 1 (TAIR:AT5G05510.1); Has 500 Blast hits to 498 proteins in 165 species: Archae - 0; Bacteria - 0; Metazoa - 213; Fungi - 157; Plants - 105; Viruses - 0; Other Eukaryotes - 25 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14213601..14216054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128916.3 → NP_565767.1  BUB1-related (BUB1: budding uninhibited by benzymidazol 1) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565767.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IFV2, O22806, Q8L9V1
      UniProtKB/TrEMBL
      A0A178VTK5, A0A5S9X3J8, A0A7G2EB05
      Conserved Domains (1) summary
      pfam08311
      Location:64 → 185
      Mad3_BUB1_I; Mad3/BUB1 homology region 1

    2. NM_001202739.2 → NP_001189668.1  BUB1-related (BUB1: budding uninhibited by benzymidazol 1) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189668.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VU51, A0A7G2EB06
      Conserved Domains (1) summary
      pfam08311
      Location:64 → 185
      Mad3_BUB1_I; Mad3/BUB1 homology region 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22806.2

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