MPK4 MAP kinase 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MPK4
Official Full Name: MAP kinase 4
Primary source: TAIR:AT4G01370
Locus tag: AT4G01370
See related: Araport:AT4G01370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATMPK4; F2N1.1; F2N1_1; MAP kinase 4; MAPK4
Summary: Encodes a nuclear and cytoplasmically localized MAP kinase involved in mediating responses to pathogens. Its substrates include MKS1 and probably MAP65-1.The MAP65-1 interaction is involved in mediating cortical microtuble organization. Required for male-specific meiotic cytokinesis.
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Genomic context

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See MPK4 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 6

Sequence:: Chromosome: 4; NC_003075.7 (566917..570299)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identify BnMPK4 interacting proteins in the absence and presence of flg22. Quantitative proteomic analysis revealed a shift in the MPK4-associated protein network, providing insight into the molecular functions of MPK4 at the systems level.
Title: MPK4 Phosphorylation Dynamics and Interacting Proteins in Plant Immunity.
key component mediating CO2 -induced stomatal movements
Title: Mitogen-activated protein kinases MPK4 and MPK12 are key components mediating CO(2) -induced stomatal movements.
H2S inhibited the opening of stomata under cold stress, which required the participation of MPK4. In conclusion, MPK4 is a downstream component of H2S-related cold-stress resistance, and H2S and MPK4 both regulated the cold response genes and stomatal movement to response the cold stress.
Title: Hydrogen sulfide alleviates the cold stress through MPK4 in Arabidopsis thaliana.
Proteome changes associated with MPK4 and MPK6 deficiency in Arabidopsis roots.
Title: Comparative proteomic study of Arabidopsis mutants mpk4 and mpk6.
AvrRpt2 specifically blocks the flagellin-induced activation of MPK4.
Title: Bacterial AvrRpt2-Like Cysteine Proteases Block Activation of the Arabidopsis Mitogen-Activated Protein Kinases, MPK4 and MPK11.
Data show that MPK4 phosphorylation of MYB75 increases its stability and is essential for light-induced anthocyanin accumulation. Our findings reveal an important role for a MAPK pathway in light signal transduction.
Title: MYB75 Phosphorylation by MPK4 Is Required for Light-Induced Anthocyanin Accumulation in Arabidopsis.
ASR3 functions as a transcriptional repressor regulated by microbe-associated molecular patterns-activated MPK4 to fine-tune plant immune gene expression.
Title: Phosphorylation of trihelix transcriptional repressor ASR3 by MAP KINASE4 negatively regulates Arabidopsis immunity.
Mitogen-activated protein kinase 4 is a salicylic acid-independent regulator of growth but not of photosynthesis in Arabidopsis
Title: Mitogen-activated protein kinase 4 is a salicylic acid-independent regulator of growth but not of photosynthesis in Arabidopsis.
Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 activation concomitantly with MEKK1 and MKK2 phosphorylation.
Title: Membrane rigidification functions upstream of the MEKK1-MKK2-MPK4 cascade during cold acclimation in Arabidopsis thaliana.
Data indicate that MEKK2 is required for the mekk1, mkk1 mkk2, and mpk4 autoimmune phenotypes.
Title: Deletion of a tandem gene family in Arabidopsis: increased MEKK2 abundance triggers autoimmunity when the MEKK1-MKK1/2-MPK4 signaling cascade is disrupted.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_116367.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to carbon dioxide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cortical microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokinesis by cell plate formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hypotonic salinity response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within jasmonic acid and ethylene-dependent systemic resistance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within jasmonic acid and ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within male meiosis cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pollen development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen tube guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stomatal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stomatal movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to cold	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to salt stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within systemic acquired resistance, salicylic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within systemic acquired resistance, salicylic acid mediated signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell plate	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MAP kinase 4

NP_192046.1

MAP kinase 4 (MPK4); FUNCTIONS IN: MAP kinase activity, kinase activity; INVOLVED IN: in 14 processes; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), JNK MAP kinase (InterPro:IPR008351), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), MAP kinase, conserved site (InterPro:IPR003527), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: MAP kinase 11 (TAIR:AT1G01560.2); Has 123445 Blast hits to 122024 proteins in 4656 species: Archae - 100; Bacteria - 13145; Metazoa - 47072; Fungi - 12439; Plants - 29862; Viruses - 477; Other Eukaryotes - 20350 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

566917..570299

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_116367.3 → NP_192046.1 MAP kinase 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192046.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B2BDE5, B2BDE6, B2BDE8, B2BDG2, O04597, Q39024, Q45V20, Q9M136

UniProtKB/TrEMBL

A0A178UXX1, A0A5S9XPM1, A0A654FKU6

Conserved Domains (1) summary

cd07858
Location:36 → 372

STKc_TEY_MAPK; Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases