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    HMGS hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826788, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HMGS
    Official Full Name
    hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase
    Primary source
    TAIR:AT4G11820
    Locus tag
    AT4G11820
    See related
    Araport:AT4G11820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EMB2778; EMBRYO DEFECTIVE 2778; FKP1; FLAKY POLLEN 1; HMG-COA SYNTHASE; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; MVA1; T26M18.30; T26M18_30
    Summary
    Encodes a protein with hydroxymethylglutaryl-CoA synthase activity which was characterized by phenotypical complementation of the S. cerevisiae mutant.
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    Genomic context

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    See HMGS in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    14
    Sequence:
    Chromosome: 4; NC_003075.7 (7108884..7112480, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Major Facilitator Superfamily with SPX (SYG1/Pho81/XPR1) domain-containing protein Neighboring gene phospholipase D gamma 2 Neighboring gene phospholipase D gamma 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of HMG-CoA synthase promotes Arabidopsis root growth and adversely affects glucosinolate biosynthesis. Liao P, et al. J Exp Bot, 2020 Jan 1. PMID 31557302, Free PMC Article
    2. The Arabidopsis FLAKY POLLEN1 gene encodes a 3-hydroxy-3-methylglutaryl-coenzyme A synthase required for development of tapetum-specific organelles and fertility of pollen grains. Ishiguro S, et al. Plant Cell Physiol, 2010 Jun. PMID 20484369
    3. Isolation and characterization of a cDNA encoding Arabidopsis thaliana 3-hydroxy-3-methylglutaryl-coenzyme A synthase. Montamat F, et al. Gene, 1995 Dec 29. PMID 8566777
    4. Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism. Lange BM, et al. Plant Mol Biol, 2003 Apr. PMID 12777052
    5. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of HMG-CoA synthase promotes Arabidopsis root growth and adversely affects glucosinolate biosynthesis.
      Title: Overexpression of HMG-CoA synthase promotes Arabidopsis root growth and adversely affects glucosinolate biosynthesis.
    2. FLAKY POLLEN1 is required for organelle development in tapetal cells and pollen coat formation. [FKP1]
      Title: The Arabidopsis FLAKY POLLEN1 gene encodes a 3-hydroxy-3-methylglutaryl-coenzyme A synthase required for development of tapetum-specific organelles and fertility of pollen grains.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001340735.1
    NM_117251.3
    NM_179030.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables acetyl-CoA C-acetyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables hydroxymethylglutaryl-CoA synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables hydroxymethylglutaryl-CoA synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, mevalonate pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase
    NP_001319906.1
    • HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HMGS); CONTAINS InterPro DOMAIN/s: Hydroxymethylglutaryl-coenzyme A synthase C-terminal (InterPro:IPR013746), Thiolase-like (InterPro:IPR016039), Hydroxymethylglutaryl-coenzyme A synthase, N-terminal (InterPro:IPR013528), Hydroxymethylglutaryl-CoA synthase, eukaryotic (InterPro:IPR010122), Hydroxymethylglutaryl-coenzyme A synthase, active site (InterPro:IPR000590); Has 2141 Blast hits to 2138 proteins in 847 species: Archae - 222; Bacteria - 1037; Metazoa - 301; Fungi - 182; Plants - 116; Viruses - 0; Other Eukaryotes - 283 (source: NCBI BLink).
    NP_192919.1
    • MVA1; CONTAINS InterPro DOMAIN/s: Thiolase-like (InterPro:IPR016039), Hydroxymethylglutaryl-coenzyme A synthase C-terminal (InterPro:IPR013746), Hydroxymethylglutaryl-coenzyme A synthase, N-terminal (InterPro:IPR013528), Hydroxymethylglutaryl-CoA synthase, eukaryotic (InterPro:IPR010122), Hydroxymethylglutaryl-coenzyme A synthase, active site (InterPro:IPR000590); Has 2176 Blast hits to 2172 proteins in 850 species: Archae - 228; Bacteria - 1039; Metazoa - 300; Fungi - 184; Plants - 117; Viruses - 0; Other Eukaryotes - 308 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      7108884..7112480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117251.3 → NP_192919.1  hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192919.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54873, Q8L721, Q9S707
      UniProtKB/TrEMBL
      A0A178V7M2, A0A5S9XS43
      Conserved Domains (3) summary
      PLN02577
      Location:1 → 461
      PLN02577; hydroxymethylglutaryl-CoA synthase
      pfam08540
      Location:175 → 451
      HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
      cl09938
      Location:4 → 174
      cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

    2. NM_179030.1 → NP_849361.1  hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849361.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V7M2, A0A5S9XS43
      Conserved Domains (3) summary
      PLN02577
      Location:1 → 406
      PLN02577; hydroxymethylglutaryl-CoA synthase
      pfam08540
      Location:120 → 396
      HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
      cl09938
      Location:1 → 119
      cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

    3. NM_001340735.1 → NP_001319906.1  hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V7M2, A0A5S9XS43
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54873.2

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