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    HhH-GPD base excision DNA repair family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826886, updated on 18-Sep-2024

    Summary

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    Official Full Name
    HhH-GPD base excision DNA repair family protein
    Primary source
    TAIR:AT4G12740
    Locus tag
    AT4G12740
    See related
    Araport:AT4G12740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T20K18.90; T20K18_90
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (7494388..7497627, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Homeodomain-like transcriptional regulator Neighboring gene RPA-interacting protein A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables purine-specific mismatch base pair DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    HhH-GPD base excision DNA repair family protein
    NP_193010.2
    • HhH-GPD base excision DNA repair family protein; FUNCTIONS IN: hydrolase activity, catalytic activity; INVOLVED IN: DNA repair, base-excision repair; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), DNA glycosylase (InterPro:IPR011257), NUDIX hydrolase domain (InterPro:IPR000086), HhH-GPD domain (InterPro:IPR003265); Has 55833 Blast hits to 29061 proteins in 2861 species: Archae - 372; Bacteria - 10631; Metazoa - 17750; Fungi - 4523; Plants - 1695; Viruses - 834; Other Eukaryotes - 20028 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      7494388..7497627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001340800.1 → NP_001329635.1  HhH-GPD base excision DNA repair family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V2R6, A0A1P8B8B5

    2. NM_001340801.1 → NP_001329634.1  HhH-GPD base excision DNA repair family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8A7, A0A5S9XTH2

    3. NM_117343.2 → NP_193010.2  HhH-GPD base excision DNA repair family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193010.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JRF4, Q9SU12
      UniProtKB/TrEMBL
      A0A5S9XTH2
      Conserved Domains (3) summary
      COG1194
      Location:122 → 529
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]
      cd00056
      Location:162 → 337
      ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
      cd03431
      Location:384 → 529
      DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JRF4.1

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