UVI4-LIKE UV-B-insensitive 4-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: UVI4-LIKE
Official Full Name: UV-B-insensitive 4-like protein
Primary source: TAIR:AT3G57860
Locus tag: AT3G57860
See related: Araport:AT3G57860
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: GIG1; GIGAS CELL 1; OMISSION OF SECOND DIVISION; OSD1; UV-B-insensitive 4-like
Summary: Encodes a protein that controls entry into the second meiotic division. Negatively regulates the Anaphase-Promoting Complex/Cyclosome.
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Genomic context

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See UVI4-LIKE in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 3

Sequence:: Chromosome: 3; NC_003074.8 (21426285..21428340)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PANS1 is expressed mainly in meiosis I where it has an important function; PANS1 and OSD1 are part of a network linking centromere cohesion and cell cycle progression through control of Anaphase Promoting Complex/Cyclosome (APC/C) activity.
Title: PATRONUS1 is expressed in meiotic prophase I to regulate centromeric cohesion in Arabidopsis and shows synthetic lethality with OSD1.
CPR5 has a large role in cell cycle regulation and this role has a complex interaction with that of UVI4 and OSD1.
Title: Interaction of CPR5 with cell cycle regulators UVI4 and OSD1 in Arabidopsis.
A functional network composed of OSD1, CYCA1;2/TAM, and TDM controls three key steps of meiotic progression, in which OSD1 is a meiotic APC/C inhibitor. [OSD1]
Title: OSD1 promotes meiotic progression via APC/C inhibition and forms a regulatory network with TDM and CYCA1;2/TAM.
These findings suggest that endomitosis and endoreplication are regulated by similar molecular mechanisms, in which two related proteins, GIG1 and UVI4, may inhibit APC/C in different ways.
Title: Roles of GIG1 and UVI4 in genome duplication in Arabidopsis thaliana.
We thus propose that a functional network composed of OSD1, CYCA1;2/TAM, and TDM controls three key steps of meiotic progression, in which OSD1 is a meiotic APC/C inhibitor.
Title: OSD1 promotes meiotic progression via APC/C inhibition and forms a regulatory network with TDM and CYCA1;2/TAM.
GIGAS CELL1 (GIG1)/OMISSION OF SECOND DIVISION1 (OSD1) and UVI4 encode novel plant-specific inhibitors of the anaphase-promoting complex/cyclosome ubiquitin ligase.
Title: GIGAS CELL1, a novel negative regulator of the anaphase-promoting complex/cyclosome, is required for proper mitotic progression and cell fate determination in Arabidopsis.
Combining tam and osd1 mutations leads to a failure in the prophase to meiosis I transition during male meiosis and to the production of tetraploid spores and gametes. [OSD1]
Title: The cyclin-A CYCA1;2/TAM is required for the meiosis I to meiosis II transition and cooperates with OSD1 for the prophase to first meiotic division transition.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_115648.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within endomitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosperm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in megagametogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiosis II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ubiquitin protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: UV-B-insensitive 4-like protein

NP_191345.1

UV-B-insensitive 4-like (UVI4-LIKE); BEST Arabidopsis thaliana protein match is: uv-b-insensitive 4 (TAIR:AT2G42260.1); Has 46 Blast hits to 46 proteins in 9 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 46; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).