MIND septum site-determining protein (MIND) [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MIND
Official Full Name: septum site-determining protein (MIND)
Primary source: TAIR:AT5G24020
Locus tag: AT5G24020
See related: Araport:AT5G24020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ACCUMULATION AND REPLICATION OF CHLOROPLASTS 11; ARC11; ATMIND1; MZF18.10; MZF18_10
Summary: Encodes a Ca2+ dependent ATPase required for correct positioning of the chloroplast division apparatus. Its ATPase activity is stimulated by AtMinE1, a topological specificity factor.
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Genomic context

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See MIND in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 1

Sequence:: Chromosome: 5; NC_003076.8 (8116665..8118087)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

required for symmetrical division of chloroplasts in leaf epidermis
Title: The Arabidopsis minD mutation causes aberrant FtsZ1 ring placement and moderate heterogeneity of chloroplasts in the leaf epidermis.
Results suggest that ARC3 directly inhibits Z-ring assembly through interaction with FtsZ2 in heteropolymers and that ARC3 activity is spatially regulated by MinD1 and MinE1 to permit Z-ring assembly at the mid-plastid.
Title: Chloroplast division protein ARC3 regulates chloroplast FtsZ-ring assembly and positioning in arabidopsis through interaction with FtsZ2.
the localization and functionality of AtMinD1 (Arabidopsis thaliana MinD) fused with a dual hemagglutinin epitope (dHA) or a yellow fluorescent protein (YFP)
Title: Further evaluation of the localization and functionality of hemagglutinin epitope- and fluorescent protein-tagged AtMinD1 in Arabidopsis thaliana.
The chloroplast division site placement involves a balance between the opposing activities of AtMinE1 and AtMinD1, which acts to prevent FtsZ ring formation anywhere outside of the mid-chloroplast.
Title: The assembly of the FtsZ ring at the mid-chloroplast division site depends on a balance between the activities of AtMinE1 and ARC11/AtMinD1.
Correct intraplastidic MinD1 localization is dependent on AtMinE1-stimulated, Ca2+-dependent AtMinD1 ATP hydrolysis
Title: The plastid division protein AtMinD1 is a Ca2+-ATPase stimulated by AtMinE1.
formation of functional AtMinD1 homodimers is paramount for appropriate AtMinD1 localization, ultimately ensuring correct division machinery placement and chloroplast division in plants
Title: Chloroplast division site placement requires dimerization of the ARC11/AtMinD1 protein in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_122307.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	TAS Traceable Author Statement more info	PubMed
enables calcium-dependent ATPase activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloroplast fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloroplast fission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed

General protein information

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Preferred Names: septum site-determining protein (MIND)

NP_197790.1

MIND; FUNCTIONS IN: calcium-dependent ATPase activity, protein binding, ATPase activity, protein homodimerization activity; INVOLVED IN: chloroplast fission; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Septum site-determining protein MinD (InterPro:IPR010223), Cobyrinic acid a,c-diamide synthase (InterPro:IPR002586); BEST Arabidopsis thaliana protein match is: IND1(iron-sulfur protein required for NADH dehydrogenase)-like (TAIR:AT4G19540.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

8116665..8118087

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_122307.3 → NP_197790.1 septum site-determining protein (MIND) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197790.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9MBA2

UniProtKB/TrEMBL

A0A178UDI3, A0A5S9Y6N9, A0A654G3W4

Conserved Domains (1) summary

cd02036
Location:59 → 300

MinD; septum site-determining protein MinD