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    CDKC2 cyclin dependent kinase group C2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836620, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDKC2
    Official Full Name
    cyclin dependent kinase group C2
    Primary source
    TAIR:AT5G64960
    Locus tag
    AT5G64960
    See related
    Araport:AT5G64960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CDKC;2; cyclin dependent kinase group C2; Cyclin-dependent kinase C;2; MXK3.19; MXK3_19
    Summary
    Encodes CDKC;2, part of a CDKC kinase complex that is targeted by Cauliflower mosaic virus (CaMV) for transcriptional activation of viral genes. Also regulates plant growth and development. Co-localizes with spliceosomal components in a manner dependent on the transcriptional status of the cells and on CDKC2-kinase activity. Expression of CDKC2 modifies the location of spliceosomal components.
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    Genomic context

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    See CDKC2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (25955374..25958995)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ABC2 homolog 13 Neighboring gene Mitochondrial transcription termination factor family protein Neighboring gene Mitochondrial substrate carrier family protein Neighboring gene transcription factor Neighboring gene RAB GTPase homolog H1A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of CDKC;2 increases both cell division and drought tolerance in Arabidopsis thaliana. Zhao L, et al. Plant J, 2017 Sep. PMID 28622431
    2. A cyclin-dependent protein kinase, CDKC2, colocalizes with and modulates the distribution of spliceosomal components in Arabidopsis. Kitsios G, et al. Plant J, 2008 Apr. PMID 18208522
    3. Antisense-mediated FLC transcriptional repression requires the P-TEFb transcription elongation factor. Wang ZW, et al. Proc Natl Acad Sci U S A, 2014 May 20. PMID 24799695, Free PMC Article
    4. Modulation of RNA polymerase II phosphorylation downstream of pathogen perception orchestrates plant immunity. Li F, et al. Cell Host Microbe, 2014 Dec 10. PMID 25464831, Free PMC Article
    5. Roles of Arabidopsis cyclin-dependent kinase C complexes in cauliflower mosaic virus infection, plant growth, and development. Cui X, et al. Plant Cell, 2007 Apr. PMID 17468259, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results reveal The crucial role of CDKC;2 in modulating both cell division and the drought response in Arabidopsis.
      Title: Loss of CDKC;2 increases both cell division and drought tolerance in Arabidopsis thaliana.
    2. cdkc;2 specifically reduces transcription of COOLAIR antisense transcripts, which indirectly up-regulates FLC expression through disruption of a COOLAIR-mediated repression mechanism.
      Title: Antisense-mediated FLC transcriptional repression requires the P-TEFb transcription elongation factor.
    3. The function and metabolism of CDKC2 is reported.
      Title: A cyclin-dependent protein kinase, CDKC2, colocalizes with and modulates the distribution of spliceosomal components in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001085328.2
    NM_125895.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within carpel development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of viral process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to virus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cyclin dependent kinase group C2
    NP_001078797.1
    • cyclin dependent kinase group C2 (CDKC2); FUNCTIONS IN: kinase activity; INVOLVED IN: in 6 processes; LOCATED IN: cytosol, nuclear body, nucleus, microtubule, spliceosomal complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: cyclin-dependent kinase C;1 (TAIR:AT5G10270.1); Has 123595 Blast hits to 117864 proteins in 4086 species: Archae - 72; Bacteria - 13038; Metazoa - 48540; Fungi - 13012; Plants - 28885; Viruses - 501; Other Eukaryotes - 19547 (source: NCBI BLink).
    NP_201301.1
    • cyclin dependent kinase group C2 (CDKC2); FUNCTIONS IN: kinase activity; INVOLVED IN: in 6 processes; LOCATED IN: cytosol, nuclear body, nucleus, microtubule, spliceosomal complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cyclin-dependent kinase C;1 (TAIR:AT5G10270.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25955374..25958995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001085328.2 → NP_001078797.1  cyclin dependent kinase group C2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078797.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UIR6, F4KGG0
      Conserved Domains (1) summary
      cd07840
      Location:11 → 272
      STKc_CDK9_like; Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases

    2. NM_125895.5 → NP_201301.1  cyclin dependent kinase group C2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201301.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8W4P1, Q9LV82
      UniProtKB/TrEMBL
      A0A178UIR6, A0A5S9YHV3, A0A654GE50
      Conserved Domains (1) summary
      cd07840
      Location:26 → 325
      STKc_CDK9_like; Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W4P1.2

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