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    ANX2 Malectin/receptor-like protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832975, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ANX2
    Official Full Name
    Malectin/receptor-like protein kinase family protein
    Primary source
    TAIR:AT5G28680
    Locus tag
    AT5G28680
    See related
    Araport:AT5G28680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ANXUR2; F4I4.60; F4I4_60
    Summary
    Receptor-like kinase required for maintenance of pollen tube growth. Display polar localization at the plasma membrane of the pollen tube tip.
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    Genomic context

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    See ANX2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (10719127..10722361, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene carboxylate clamp-TPR protein (DUF1685) Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structures of the extracellular domains of the CrRLK1L receptor-like kinases ANXUR1 and ANXUR2. Du S, et al. Protein Sci, 2018 Apr. PMID 29388293, Free PMC Article
    2. Differential Regulation of Two-Tiered Plant Immunity and Sexual Reproduction by ANXUR Receptor-Like Kinases. Mang H, et al. Plant Cell, 2017 Dec. PMID 29150546, Free PMC Article
    3. T-DNA-induced chromosomal translocations in feronia and anxur2 mutants reveal implications for the mechanism of collapsed pollen due to chromosomal rearrangements. Ruprecht C, et al. Mol Plant, 2014 Oct. PMID 24874868
    4. ANXUR1 and 2, sister genes to FERONIA/SIRENE, are male factors for coordinated fertilization. Miyazaki S, et al. Curr Biol, 2009 Aug 11. PMID 19646876
    5. Disruption of the pollen-expressed FERONIA homologs ANXUR1 and ANXUR2 triggers pollen tube discharge. Boisson-Dernier A, et al. Development, 2009 Oct. PMID 19736323, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. uncoupled functions of ANX1 and ANX2 during plant immunity and sexual reproduction, are reported.
      Title: Differential Regulation of Two-Tiered Plant Immunity and Sexual Reproduction by ANXUR Receptor-Like Kinases.
    2. Crystal structure shows that ANX2 extracellular domain lack residues involved in binding to the diglucosides.
      Title: Crystal structures of the extracellular domains of the CrRLK1L receptor-like kinases ANXUR1 and ANXUR2.
    3. Three independent T-DNA insertion lines for FERONIA and its pollen-specific homolog ANXUR2 showing deformed pollen phenotypes caused by chromosomal translocations, were identified.
      Title: T-DNA-induced chromosomal translocations in feronia and anxur2 mutants reveal implications for the mechanism of collapsed pollen due to chromosomal rearrangements.
    4. study reports that pollen tubes of anx1/anx2 mutants ruptured before arriving at the egg apparatus, suggesting that ANX1(At3g04690) and ANX2(At5g28680)are male factors controlling pollen tube behavior by directing rupture at proper timing
      Title: ANXUR1 and 2, sister genes to FERONIA/SIRENE, are male factors for coordinated fertilization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001344080.1
    NM_122751.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within pollen tube growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in pollen tube tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Malectin/receptor-like protein kinase family protein
    NP_001318669.1
    • ANXUR2 (ANX2); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: pollen tube growth; LOCATED IN: apical plasma membrane; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Malectin/receptor-like protein kinase (InterPro:IPR021720), Protein kinase, catalytic domain (InterPro:IPR000719), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Malectin/receptor-like protein kinase family protein (TAIR:AT3G04690.1); Has 115671 Blast hits to 114295 proteins in 4417 species: Archae - 97; Bacteria - 12752; Metazoa - 43268; Fungi - 9644; Plants - 32773; Viruses - 427; Other Eukaryotes - 16710 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      10719127..10722361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001344080.1 → NP_001318669.1  Malectin/receptor-like protein kinase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3E8W4
      UniProtKB/TrEMBL
      A0A654G521
      Conserved Domains (4) summary
      smart00221
      Location:526 → 788
      STYKc; Protein kinase; unclassified specificity
      cd14066
      Location:527 → 792
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam11721
      Location:213 → 367
      Malectin; Di-glucose binding within endoplasmic reticulum
      pfam12819
      Location:32 → 399
      Malectin_like; Carbohydrate-binding protein of the ER

    2. NM_122751.2 → NP_198220.1  Malectin/receptor-like protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198220.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3E8W4
      UniProtKB/TrEMBL
      A0A654G521
      Conserved Domains (4) summary
      smart00221
      Location:526 → 788
      STYKc; Protein kinase; unclassified specificity
      cd14066
      Location:527 → 792
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam11721
      Location:213 → 367
      Malectin; Di-glucose binding within endoplasmic reticulum
      pfam12819
      Location:32 → 399
      Malectin_like; Carbohydrate-binding protein of the ER
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E8W4.1

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