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    SPX1 SPX domain-containing protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832137, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SPX1
    Official Full Name
    SPX domain-containing protein 1
    Primary source
    TAIR:AT5G20150
    Locus tag
    AT5G20150
    See related
    Araport:AT5G20150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA SPX DOMAIN GENE 1; ARABIDOPSIS THALIANA SPX DOMAIN GENE 1; ATSPX1; F5O24.40; F5O24_40; SPX domain gene 1; SPX domain gene 1
    Summary
    Expression is upregulated in the shoot of cax1/cax3 mutant.
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    Genomic context

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    See SPX1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (6802282..6803655)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene testis- and ovary-specific PAZ domain protein Neighboring gene sulfate adenylyltransferase subunit Neighboring gene SOUL heme-binding family protein Neighboring gene Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein Neighboring gene kish-A-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtSPX1-mediated transcriptional regulation during leaf senescence in Arabidopsis thaliana. Yan H, et al. Plant Sci, 2019 Jun. PMID 31128694
    2. Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis. Ried MK, et al. Nat Commun, 2021 Jan 15. PMID 33452263, Free PMC Article
    3. AtSPX1 affects the AtPHR1-DNA-binding equilibrium by binding monomeric AtPHR1 in solution. Qi W, et al. Biochem J, 2017 Oct 23. PMID 28887383, Free PMC Article
    4. SPX1 is a phosphate-dependent inhibitor of Phosphate Starvation Response 1 in Arabidopsis. Puga MI, et al. Proc Natl Acad Sci U S A, 2014 Oct 14. PMID 25271326, Free PMC Article
    5. Characterization of a sub-family of Arabidopsis genes with the SPX domain reveals their diverse functions in plant tolerance to phosphorus starvation. Duan K, et al. Plant J, 2008 Jun. PMID 18315545

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis.
      Title: Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis.
    2. mediates transcriptional regulation during leaf senescence
      Title: AtSPX1-mediated transcriptional regulation during leaf senescence in Arabidopsis thaliana.
    3. These data suggest that, in the Pi-restored condition, AtSPX1 can bind to monomeric AtPHR1 in solution and therefore regulate PSI gene expression by tuning the AtPHR1-DNA-binding equilibrium.
      Title: AtSPX1 affects the AtPHR1-DNA-binding equilibrium by binding monomeric AtPHR1 in solution.
    4. The relative strength of the SPX1/PHR1 interaction is thus directly influenced by phosphate (Pi), providing a link between Pi perception and signaling.
      Title: SPX1 is a phosphate-dependent inhibitor of Phosphate Starvation Response 1 in Arabidopsis.
    5. AtSPX1 and AtSPX3 play positive roles in plant adaptation to phosphate starvation, and AtSPX3 may have a negative feedback regulatory role in AtSPX1 response to phosphate starvation.
      Title: Characterization of a sub-family of Arabidopsis genes with the SPX domain reveals their diverse functions in plant tolerance to phosphorus starvation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_122022.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within cellular response to phosphate starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cellular response to phosphate starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SPX domain-containing protein 1
    NP_197515.1
    • SPX domain gene 1 (SPX1); CONTAINS InterPro DOMAIN/s: SPX, N-terminal (InterPro:IPR004331); BEST Arabidopsis thaliana protein match is: SPX domain gene 2 (TAIR:AT2G26660.1); Has 1126 Blast hits to 1124 proteins in 197 species: Archae - 3; Bacteria - 7; Metazoa - 241; Fungi - 471; Plants - 313; Viruses - 0; Other Eukaryotes - 91 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      6802282..6803655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122022.3 → NP_197515.1  SPX domain-containing protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197515.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LBH4, Q8RY68
      UniProtKB/TrEMBL
      A0A178UFB1, A0A5S9Y679, A0A654G2V5
      Conserved Domains (1) summary
      cd14481
      Location:2 → 144
      SPX_AtSPX1_like; SPX domain of the plant protein SPX1 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LBH4.2

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