U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tbck TBC1 domain containing kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295446, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tbckprovided by RGD
    Official Full Name
    TBC1 domain containing kinaseprovided by RGD
    Primary source
    RGD:1307816
    See related
    EnsemblRapid:ENSRNOG00000011454 AllianceGenome:RGD:1307816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tbckl; RGD1307816
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in actin cytoskeleton organization; cell population proliferation; and regulation of TOR signaling. Predicted to be located in cytoplasm; midbody; and mitotic spindle. Human ortholog(s) of this gene implicated in infantile hypotonia with psychomotor retardation and characteristic facies-3. Orthologous to human TBCK (TBC1 domain containing kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 77.1), Lung (RPKM 56.9) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tbck in Genome Data Viewer
    Location:
    2q43
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (223849758..224022097)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (221175749..221348058)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (237751646..237958497)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547683 Neighboring gene GIMAP family P-loop NTPase domain containing 1 Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene nephronectin Neighboring gene MTOR associated protein, eak-7 homolog, pseudogene 1 Neighboring gene uncharacterized LOC102548236

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TBC domain-containing protein kinase-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415033.1NP_001401962.1  TBC domain-containing protein kinase-like protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K9Q0, A0A8I6ALH8
      Related
      ENSRNOP00000075082.2, ENSRNOT00000083937.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      223849758..224022097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102101.2XP_038958029.1  TBC domain-containing protein kinase-like protein isoform X2

      Conserved Domains (3) summary
      COG5210
      Location:335546
      COG5210; GTPase-activating protein [General function prediction only]
      cl02495
      Location:467546
      RabGAP-TBC; Rab-GTPase-TBC domain
      cl21453
      Location:43273
      PKc_like; Protein Kinases, catalytic domain
    2. XM_063281663.1XP_063137733.1  TBC domain-containing protein kinase-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALH8
    3. XM_039102098.2XP_038958026.1  TBC domain-containing protein kinase-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALH8
      Conserved Domains (3) summary
      smart00164
      Location:328532
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cl00125
      Location:633744
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
      cl21453
      Location:11134
      PKc_like; Protein Kinases, catalytic domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001134513.1: Suppressed sequence

      Description
      NM_001134513.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.