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    Terc telomerase RNA component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 378461, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tercprovided by RGD
    Official Full Name
    telomerase RNA componentprovided by RGD
    Primary source
    RGD:727802
    See related
    AllianceGenome:RGD:727802
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tr
    Summary
    Predicted to enable DNA polymerase binding activity; WD40-repeat domain binding activity; and template for synthesis of G-rich strand of telomere DNA activity. Predicted to contribute to telomerase activity. Involved in negative regulation of cell differentiation. Predicted to be located in Cajal body; chromosome, telomeric region; and cytoplasm. Predicted to be part of box H/ACA telomerase RNP complex and telomerase catalytic core complex. Human ortholog(s) of this gene implicated in autosomal dominant dyskeratosis congenita 1; cervix uteri carcinoma in situ; melanoma; and prostate cancer. Orthologous to human TERC (telomerase RNA component). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Terc in Genome Data Viewer
    Location:
    2q24
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (114744148..114744535)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (112815654..112816041)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (116432723..116433110)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene myoneurin Neighboring gene transfer RNA valine (anticodon AAC) 1 Neighboring gene actin-related protein T3 Neighboring gene serine/arginine-rich splicing factor 7 pseudogene Neighboring gene uncharacterized LOC120100572

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of the human telomerase reverse transcriptase is not related to telomerase activity in normal and malignant renal tissue. Rohde V, et al. Clin Cancer Res, 2000 Dec. PMID 11156238
    2. Telomerase as a prognostic marker in breast cancer: high-throughput tissue microarray analysis of hTERT and hTR. Poremba C, et al. J Pathol, 2002 Oct. PMID 12237877
    3. Telomere length, telomerase activity and telomerase RNA expression during mouse mammary tumor progression. Kiyozuka Y, et al. Int J Mol Med, 1998 Oct. PMID 9857231
    4. Up-regulation of telomerase in primary cultured rat hepatocytes. Nozawa K, et al. J Biochem, 1999 Aug. PMID 10423530
    5. Genomic integration of oncogenic HPV and gain of the human telomerase gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer. Hopman AH, et al. J Pathol, 2006 Dec. PMID 17054308

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to RNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables WD40-repeat domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to telomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables telomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables template for synthesis of G-rich strand of telomere DNA activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables template for synthesis of G-rich strand of telomere DNA activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance via telomerase TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of box H/ACA telomerase RNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of telomerase catalytic core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_001567.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF221916

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      114744148..114744535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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