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    Cda cytidine deaminase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362638, updated on 9-Dec-2024

    Summary

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    Symbol
    Cdaprovided by RGD
    Full Name
    cytidine deaminaseprovided by RGD
    Primary source
    RGD:1311101
    See related
    EnsemblRapid:ENSRNOG00000015677 AllianceGenome:RGD:1311101
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables cytidine deaminase activity. Involved in cellular response to external biotic stimulus; cytidine deamination; and response to cycloheximide. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CDA (cytidine deaminase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 13.5), Heart (RPKM 11.9) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cda in Genome Data Viewer
    Location:
    5q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (155839929..155866541, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (150556615..150583231, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (156703579..156734541, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Neighboring gene PTEN induced kinase 1 Neighboring gene uncharacterized LOC134487022 Neighboring gene family with sequence similarity 43, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Pyrimidine nucleotide synthesis in rat liver after the administration of cycloheximide. Seifert J, et al. Toxicology, 1978 May. PMID 675715
    2. Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism. Sugiyama E, et al. J Clin Oncol, 2007 Jan 1. PMID 17194903
    3. Structure of human cytidine deaminase bound to a potent inhibitor. Chung SJ, et al. J Med Chem, 2005 Feb 10. PMID 15689149
    4. Growth inhibition of granulocyte-macrophage colony-forming cells by human cytidine deaminase requires the catalytic function of the protein. Gran C, et al. Blood, 1998 Jun 1. PMID 9596658
    5. Development of multidrug resistance due to multiple factors including P-glycoprotein overexpression under K-selection after MYC and HRAS oncogene activation. Nakamura Y, et al. Int J Cancer, 2006 May 15. PMID 16353156

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytidine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytidine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytidine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in UMP salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to external biotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cytidine deamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytidine deamination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytidine deamination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cycloheximide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytidine deaminase
    NP_001102158.1
    XP_038966350.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108688.1 → NP_001102158.1  cytidine deaminase

      See identical proteins and their annotated locations for NP_001102158.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6ITH4, D4AC20
      Related
      ENSRNOP00000021036.4, ENSRNOT00000021036.6
      Conserved Domains (1) summary
      TIGR01354
      Location:16 → 142
      cyt_deam_tetra; cytidine deaminase, homotetrameric

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      155839929..155866541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110422.2 → XP_038966350.1  cytidine deaminase isoform X1

      Conserved Domains (1) summary
      TIGR01354
      Location:11 → 101
      cyt_deam_tetra; cytidine deaminase, homotetrameric
    Nucleotide Protein Strain
    Heading Accession and Version

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